Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4808248..4808893 Replicon chromosome
Accession NZ_CP065411
Organism Kosakonia radicincitans strain IAC-BECa95

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag I5960_RS23260 Protein ID WP_035886605.1
Coordinates 4808248..4808430 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I5960_RS23265 Protein ID WP_035943124.1
Coordinates 4808456..4808893 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5960_RS23235 4803322..4804275 - 954 WP_227136100.1 helix-turn-helix transcriptional regulator -
I5960_RS23240 4804403..4805308 - 906 WP_071920166.1 LysR family transcriptional regulator -
I5960_RS23245 4805395..4806180 + 786 WP_071920165.1 NAD(P)H-dependent oxidoreductase -
I5960_RS23250 4806372..4806944 + 573 WP_007372977.1 TetR/AcrR family transcriptional regulator -
I5960_RS23255 4807011..4808177 + 1167 WP_071920164.1 multidrug effflux MFS transporter -
I5960_RS23260 4808248..4808430 + 183 WP_035886605.1 type II toxin-antitoxin system HicA family toxin Toxin
I5960_RS23265 4808456..4808893 + 438 WP_035943124.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I5960_RS23270 4808890..4809783 - 894 WP_149289196.1 MurR/RpiR family transcriptional regulator -
I5960_RS23275 4809796..4810743 - 948 WP_035886608.1 iron-siderophore ABC transporter substrate-binding protein -
I5960_RS23280 4810758..4811810 - 1053 WP_007372972.1 iron ABC transporter permease -
I5960_RS23285 4811807..4812829 - 1023 WP_035886611.1 iron ABC transporter permease -
I5960_RS23290 4812826..4813650 - 825 WP_007372970.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6770.97 Da        Isoelectric Point: 11.0174

>T182580 WP_035886605.1 NZ_CP065411:4808248-4808430 [Kosakonia radicincitans]
MKYSEFRKWLLSQGAELTKAPGGGSHFKVRLNGRASVFPFHGSKEIPEPLRKKIMKDLGL

Download         Length: 183 bp

>T182580 NZ_CP065411:4808248-4808430 [Kosakonia radicincitans]
ATGAAATACAGCGAGTTCAGAAAGTGGTTGTTATCTCAGGGAGCGGAGCTAACCAAAGCTCCAGGTGGAGGAAGCCATTT
TAAAGTCAGGCTTAATGGTAGGGCATCGGTTTTCCCTTTTCATGGTTCGAAAGAGATTCCTGAGCCGTTGAGGAAAAAGA
TTATGAAGGACTTAGGCCTGTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 15953.41 Da        Isoelectric Point: 5.5739

>AT182580 WP_035943124.1 NZ_CP065411:4808456-4808893 [Kosakonia radicincitans]
MFNYPVHIERDDATGQFVVSCRDLPLMNSVGDTLDEALLQSIDGIVVAIAIEIDERRPIPAASAPLKGEYIVSLPVLVAM
KAALHNAMIETGTRKAELARKLGQKGPQIDRLLDVEHSSKVETVELALHQLNRQIDLTITPQHRA

Download         Length: 438 bp

>AT182580 NZ_CP065411:4808456-4808893 [Kosakonia radicincitans]
ATGTTTAATTATCCCGTCCACATTGAACGAGACGATGCTACAGGTCAGTTCGTGGTCTCATGCCGCGATCTACCGCTCAT
GAACTCCGTTGGCGATACGCTTGATGAGGCTTTACTGCAGTCGATTGATGGGATTGTTGTTGCGATTGCTATCGAAATTG
ACGAGCGGCGTCCAATCCCGGCGGCAAGCGCGCCGCTAAAAGGCGAATACATCGTATCGCTGCCCGTACTCGTAGCCATG
AAAGCCGCACTGCATAACGCCATGATCGAAACCGGGACGCGAAAAGCTGAGCTGGCAAGAAAGCTGGGACAGAAAGGGCC
GCAAATTGACCGCTTGCTCGATGTGGAGCACTCATCGAAGGTGGAAACGGTTGAACTGGCGCTACATCAGTTAAATCGAC
AGATTGATCTGACCATTACGCCGCAGCATAGAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References