Detailed information of TA system TA182577

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RHH
• Location: 3975884..3976441
• Replicon: chromosome
• Accession: NZ_CP065411
• Organism: Kosakonia radicincitans strain IAC-BECa95

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I5960_RS19355
• Protein ID: WP_072438369.1
• Coordinates: 3976166..3976441 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I5960_RS19350
• Protein ID: WP_071920458.1
• Coordinates: 3975884..3976162 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5960_RS19335	3971851..3972846	-	996	WP_007373782.1	ABC transporter permease	-
I5960_RS19340	3972843..3974345	-	1503	WP_090397329.1	sugar ABC transporter ATP-binding protein	-
I5960_RS19345	3974508..3975596	+	1089	WP_144134406.1	oxidoreductase	-
I5960_RS19350	3975884..3976162	+	279	WP_071920458.1	CopG family ribbon-helix-helix protein	Antitoxin
I5960_RS19355	3976166..3976441	+	276	WP_072438369.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I5960_RS19360	3976516..3977103	-	588	WP_007373776.1	TetR/AcrR family transcriptional regulator	-
I5960_RS19365	3977215..3977958	+	744	WP_107146338.1	3-oxoacyl-ACP reductase family protein	-
I5960_RS19370	3977978..3978175	-	198	WP_000460621.1	YbdD/YjiX family protein	-
I5960_RS19375	3978224..3980329	-	2106	WP_035886031.1	pyruvate/proton symporter CstA	-
I5960_RS19380	3980497..3980910	-	414	WP_035886032.1	proofreading thioesterase EntH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10849.63 Da
• Isoelectric Point: 5.1100

>T182577 WP_072438369.1 NZ_CP065411:3976166-3976441 [Kosakonia radicincitans]
MQLEWTRLALQDVERLSKFLFIQNPEAARKVVIMLADAPEMLLLHPQIGPPDESWYPREIRSLFVGSYEMIYELTDSHII
ILRIWHTKEDR

Nucleotide

• Length: 276 bp

>T182577 NZ_CP086500:2144418-2144521 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10078.65 Da
• Isoelectric Point: 8.6586

>AT182577 WP_071920458.1 NZ_CP065411:3975884-3976162 [Kosakonia radicincitans]
MSGTKVLTAHVPIELADKVDLLAESSERSRGWIIKRALAEYIERAELRQAMIQQGLDAVERGETVSHAEAATWLKSLGTV
NPMPLPGVKKRG

Nucleotide

• Length: 279 bp

>AT182577 NZ_CP086500:c2144559-2144288 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT