Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 547218..547903 Replicon chromosome
Accession NZ_CP065405
Organism Paraburkholderia caribensis strain IAC-BECa88

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag I5286_RS31245 Protein ID WP_227247337.1
Coordinates 547718..547903 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I5286_RS31240 Protein ID WP_054931814.1
Coordinates 547218..547637 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5286_RS31220 542677..544008 + 1332 WP_227247334.1 FAD-binding oxidoreductase -
I5286_RS31225 544005..544916 + 912 WP_054931803.1 ABC transporter permease -
I5286_RS31230 544913..545710 + 798 WP_227247335.1 ABC transporter permease -
I5286_RS31235 545731..547158 + 1428 WP_227247336.1 aldehyde dehydrogenase family protein -
I5286_RS31240 547218..547637 - 420 WP_054931814.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I5286_RS31245 547718..547903 - 186 WP_227247337.1 type II toxin-antitoxin system HicA family toxin Toxin
I5286_RS31250 547995..549710 - 1716 WP_227247338.1 GMC family oxidoreductase N-terminal domain-containing protein -
I5286_RS31255 549825..550835 - 1011 WP_227247586.1 ABC transporter substrate-binding protein -
I5286_RS31260 551086..551430 - 345 WP_054931807.1 cupin domain-containing protein -
I5286_RS31265 551475..552452 - 978 WP_054931808.1 M14 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-65)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7091.15 Da        Isoelectric Point: 11.3397

>T182551 WP_227247337.1 NZ_CP065405:c547903-547718 [Paraburkholderia caribensis]
MKYSEFRKWLKQQGATFERHRSGSSHYRVTLNGRTTIFPDHGAKEMGKGLVEAIRKQLGIR

Download         Length: 186 bp

>T182551 NZ_CP086490:2755702-2755809 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15289.71 Da        Isoelectric Point: 5.2440

>AT182551 WP_054931814.1 NZ_CP065405:c547637-547218 [Paraburkholderia caribensis]
MLSYPISLTPDDNGTLLVTFPDVPEAITVGDDEEDAKVQALDALEAAFEIYFAQKRSIPMPSKAKRGQPVVTLPALVTAK
VLLADEMLRQNVRKAELARRLSVNQVQVDRLLNFGHSSKIEMVESAFAVLGKRLDVRAV

Download         Length: 420 bp

>AT182551 NZ_CP086490:c2755655-2755589 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References