Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2055779..2056522 Replicon chromosome
Accession NZ_CP065403
Organism Paraburkholderia caribensis strain IAC-BECa88

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag I5286_RS09180 Protein ID WP_227242489.1
Coordinates 2056337..2056522 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I5286_RS09175 Protein ID WP_227242487.1
Coordinates 2055779..2056204 (-) Length 142 a.a.

Genomic Context

I5286_RS09120I5286_RS09125I5286_RS09130I5286_RS09135I5286_RS09140I5286_RS09145I5286_RS09150I5286_RS09155I5286_RS09160I5286_RS09170I5286_RS09195I5286_RS09210I5286_RS09165I5286_RS09175I5286_RS09180I5286_RS09185I5286_RS09190I5286_RS09200I5286_RS09205I5286_RS09215I5286_RS09220I5286_RS09225
Location: 2051514..2051762 (249 bp)
Type: Others
Protein ID: WP_227242470.1
Location: 2051756..2051938 (183 bp)
Type: Others
Protein ID: WP_227242472.1
Location: 2051949..2052323 (375 bp)
Type: Others
Protein ID: WP_227242473.1
Location: 2052348..2053181 (834 bp)
Type: Others
Protein ID: WP_227242475.1
Location: 2053270..2053650 (381 bp)
Type: Others
Protein ID: WP_227242476.1
Location: 2053661..2053948 (288 bp)
Type: Others
Protein ID: WP_227242478.1
Location: 2053953..2054216 (264 bp)
Type: Others
Protein ID: WP_227242479.1
Location: 2054227..2054787 (561 bp)
Type: Others
Protein ID: WP_227242481.1
Location: 2054820..2055155 (336 bp)
Type: Others
Protein ID: WP_227242482.1
Location: 2055469..2055729 (261 bp)
Type: Others
Protein ID: WP_227242485.1
Location: 2057765..2058031 (267 bp)
Type: Others
Protein ID: WP_007588017.1
Location: 2059066..2059341 (276 bp)
Type: Others
Protein ID: WP_060600505.1
Location: 2055170..2055436 (267 bp)
Type: Others
Protein ID: WP_227242484.1
Location: 2055779..2056204 (426 bp)
Type: Antitoxin
Protein ID: WP_227242487.1
Location: 2056337..2056522 (186 bp)
Type: Toxin
Protein ID: WP_227242489.1
Location: 2056624..2056938 (315 bp)
Type: Others
Protein ID: WP_227242490.1
Location: 2056938..2057228 (291 bp)
Type: Others
Protein ID: WP_227242491.1
Location: 2058368..2058619 (252 bp)
Type: Others
Protein ID: WP_054930347.1
Location: 2058669..2058869 (201 bp)
Type: Others
Protein ID: WP_054930346.1
Location: 2059418..2059633 (216 bp)
Type: Others
Protein ID: WP_012401038.1
Location: 2059679..2060590 (912 bp)
Type: Others
Protein ID: WP_227242493.1
Location: 2060587..2061417 (831 bp)
Type: Others
Protein ID: WP_054930344.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I5286_RS091202051514..2051762+249WP_227242470.1hypothetical protein-
I5286_RS091252051756..2051938+183WP_227242472.1hypothetical protein-
I5286_RS091302051949..2052323+375WP_227242473.1hypothetical protein-
I5286_RS091352052348..2053181+834WP_227242475.1hypothetical protein-
I5286_RS091402053270..2053650+381WP_227242476.1hypothetical protein-
I5286_RS091452053661..2053948+288WP_227242478.1hypothetical protein-
I5286_RS091502053953..2054216+264WP_227242479.1hypothetical protein-
I5286_RS091552054227..2054787+561WP_227242481.1hypothetical protein-
I5286_RS091602054820..2055155+336WP_227242482.1hypothetical protein-
I5286_RS091652055170..2055436-267WP_227242484.1DUF1488 family protein-
I5286_RS091702055469..2055729+261WP_227242485.1pyocin activator PrtN family protein-
I5286_RS091752055779..2056204-426WP_227242487.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
I5286_RS091802056337..2056522-186WP_227242489.1type II toxin-antitoxin system HicA family toxinToxin
I5286_RS091852056624..2056938-315WP_227242490.1DUF2591 family protein-
I5286_RS091902056938..2057228-291WP_227242491.1hypothetical protein-
I5286_RS091952057765..2058031+267WP_007588017.1hypothetical protein-
I5286_RS092002058368..2058619-252WP_054930347.1hypothetical protein-
I5286_RS092052058669..2058869-201WP_054930346.1hypothetical protein-
I5286_RS092102059066..2059341+276WP_060600505.1hypothetical protein-
I5286_RS092152059418..2059633-216WP_012401038.1molybdopterin-binding protein-
I5286_RS092202059679..2060590-912WP_227242493.1ATP-binding cassette domain-containing protein-
I5286_RS092252060587..2061417-831WP_054930344.1aliphatic sulfonate ABC transporter permease SsuC-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2012331..207045958128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-66)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7023.24 Da        Isoelectric Point: 10.9137

>T182548 WP_227242489.1 NZ_CP065403:c2056522-2056337 [Paraburkholderia caribensis]
MKYSEFKKWLTHQGATFEKHRAGSSHYRVTLKGKTTIFPFHGSKEMGTKLVEAIKKQLGIK

Download         Length: 186 bp

>T182548 NZ_CP086490:2455046-2456368 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15465.95 Da        Isoelectric Point: 5.9460

>AT182548 WP_227242487.1 NZ_CP065403:c2056204-2055779 [Paraburkholderia caribensis]
MLSYPIELKPDSNGTLLVTFPDVPEAITVGENEEDALLQGLDALEAALEIYFSEKRPIPAPSKAKRGQKVVTLPALATSK
VLLANEMLEQNVRKAELARRLKVNQVQVDRLLNFTHSSKIEMVESAFAALGKRLEVRAVAA

Download         Length: 426 bp

>AT182548 NZ_CP086490:2454780-2455046 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References