Detailed information of TA system TA182548

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2055779..2056522
• Replicon: chromosome
• Accession: NZ_CP065403
• Organism: Paraburkholderia caribensis strain IAC-BECa88

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: I5286_RS09180
• Protein ID: WP_227242489.1
• Coordinates: 2056337..2056522 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: I5286_RS09175
• Protein ID: WP_227242487.1
• Coordinates: 2055779..2056204 (-)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5286_RS09120	2051514..2051762	+	249	WP_227242470.1	hypothetical protein	-
I5286_RS09125	2051756..2051938	+	183	WP_227242472.1	hypothetical protein	-
I5286_RS09130	2051949..2052323	+	375	WP_227242473.1	hypothetical protein	-
I5286_RS09135	2052348..2053181	+	834	WP_227242475.1	hypothetical protein	-
I5286_RS09140	2053270..2053650	+	381	WP_227242476.1	hypothetical protein	-
I5286_RS09145	2053661..2053948	+	288	WP_227242478.1	hypothetical protein	-
I5286_RS09150	2053953..2054216	+	264	WP_227242479.1	hypothetical protein	-
I5286_RS09155	2054227..2054787	+	561	WP_227242481.1	hypothetical protein	-
I5286_RS09160	2054820..2055155	+	336	WP_227242482.1	hypothetical protein	-
I5286_RS09165	2055170..2055436	-	267	WP_227242484.1	DUF1488 family protein	-
I5286_RS09170	2055469..2055729	+	261	WP_227242485.1	pyocin activator PrtN family protein	-
I5286_RS09175	2055779..2056204	-	426	WP_227242487.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I5286_RS09180	2056337..2056522	-	186	WP_227242489.1	type II toxin-antitoxin system HicA family toxin	Toxin
I5286_RS09185	2056624..2056938	-	315	WP_227242490.1	DUF2591 family protein	-
I5286_RS09190	2056938..2057228	-	291	WP_227242491.1	hypothetical protein	-
I5286_RS09195	2057765..2058031	+	267	WP_007588017.1	hypothetical protein	-
I5286_RS09200	2058368..2058619	-	252	WP_054930347.1	hypothetical protein	-
I5286_RS09205	2058669..2058869	-	201	WP_054930346.1	hypothetical protein	-
I5286_RS09210	2059066..2059341	+	276	WP_060600505.1	hypothetical protein	-
I5286_RS09215	2059418..2059633	-	216	WP_012401038.1	molybdopterin-binding protein	-
I5286_RS09220	2059679..2060590	-	912	WP_227242493.1	ATP-binding cassette domain-containing protein	-
I5286_RS09225	2060587..2061417	-	831	WP_054930344.1	aliphatic sulfonate ABC transporter permease SsuC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2012331..2070459	58128

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-66)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7023.24 Da
• Isoelectric Point: 10.9137

>T182548 WP_227242489.1 NZ_CP065403:c2056522-2056337 [Paraburkholderia caribensis]
MKYSEFKKWLTHQGATFEKHRAGSSHYRVTLKGKTTIFPFHGSKEMGTKLVEAIKKQLGIK

Nucleotide

• Length: 186 bp

>T182548 NZ_CP086490:2455046-2456368 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15465.95 Da
• Isoelectric Point: 5.9460

>AT182548 WP_227242487.1 NZ_CP065403:c2056204-2055779 [Paraburkholderia caribensis]
MLSYPIELKPDSNGTLLVTFPDVPEAITVGENEEDALLQGLDALEAALEIYFSEKRPIPAPSKAKRGQKVVTLPALATSK
VLLANEMLEQNVRKAELARRLKVNQVQVDRLLNFTHSSKIEMVESAFAALGKRLEVRAVAA

Nucleotide

• Length: 426 bp

>AT182548 NZ_CP086490:2454780-2455046 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA