Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-StbC
Location 1639396..1640056 Replicon chromosome
Accession NZ_CP065403
Organism Paraburkholderia caribensis strain IAC-BECa88

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I5286_RS07190 Protein ID WP_082434037.1
Coordinates 1639628..1640056 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I5286_RS07185 Protein ID WP_035991398.1
Coordinates 1639396..1639641 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5286_RS07160 1634990..1635502 - 513 WP_035990992.1 Spy/CpxP family protein refolding chaperone -
I5286_RS07165 1635655..1636539 + 885 WP_224102400.1 LysR family transcriptional regulator -
I5286_RS07170 1636676..1637140 + 465 WP_035990996.1 Lrp/AsnC family transcriptional regulator -
I5286_RS07175 1637348..1638445 + 1098 WP_035990998.1 saccharopine dehydrogenase C-terminal domain-containing protein -
I5286_RS07180 1638606..1639226 - 621 WP_227244089.1 ATP-binding protein -
I5286_RS07185 1639396..1639641 + 246 WP_035991398.1 DNA-binding protein Antitoxin
I5286_RS07190 1639628..1640056 + 429 WP_082434037.1 type II toxin-antitoxin system VapC family toxin Toxin
I5286_RS07195 1640145..1640618 + 474 WP_227244091.1 DUF2846 domain-containing protein -
I5286_RS07200 1640823..1641800 + 978 WP_054934556.1 magnesium/cobalt transporter CorA -
I5286_RS07205 1641843..1642481 - 639 WP_227244092.1 LysE family translocator -
I5286_RS07210 1643032..1643988 + 957 WP_227244094.1 sugar ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15715.91 Da        Isoelectric Point: 7.4682

>T182547 WP_082434037.1 NZ_CP065403:1639628-1640056 [Paraburkholderia caribensis]
VYLIDTNVISEMRKSSRANPGVQAFFETAKEGGHRLYLSVVTVGELRRGVDLIRHRGDKFQALRLEGWLDTIMNSFSSHI
LNVGTDVAQTWGHLRVPDPGHSLDKLIAATALIYNLTVVTRNVADFDGTGARVLNPFQLLDA

Download         Length: 429 bp

>T182547 NZ_CP086490:2144416-2144519 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8938.90 Da        Isoelectric Point: 4.2208

>AT182547 WP_035991398.1 NZ_CP065403:1639396-1639641 [Paraburkholderia caribensis]
MANLLVRNLDDALVQNLREQAAAHGRSVEAEHREILAQALFQPRKLSFAELLMSMPDVGDDADFERRNDATDDSGGPGVF
D

Download         Length: 246 bp

>AT182547 NZ_CP086490:c2144557-2144286 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References