Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 798203..798860 Replicon chromosome
Accession NZ_CP065401
Organism Klebsiella pneumoniae strain KPNSP-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I5G01_RS03915 Protein ID WP_002916310.1
Coordinates 798450..798860 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I5G01_RS03910 Protein ID WP_002916312.1
Coordinates 798203..798469 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5G01_RS03885 793411..794844 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
I5G01_RS03890 794963..795691 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I5G01_RS03895 795741..796052 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I5G01_RS03900 796216..796875 + 660 WP_002916317.1 hemolysin III family protein -
I5G01_RS03905 796974..797957 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
I5G01_RS03910 798203..798469 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I5G01_RS03915 798450..798860 + 411 WP_002916310.1 protein YgfX Toxin
I5G01_RS03920 798867..799388 - 522 WP_002916308.1 flavodoxin FldB -
I5G01_RS03925 799489..800385 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I5G01_RS03930 800408..801121 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I5G01_RS03935 801127..802860 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T182529 WP_002916310.1 NZ_CP065401:798450-798860 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T182529 NZ_CP086482:c59297-59148 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT182529 WP_002916312.1 NZ_CP065401:798203-798469 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT182529 NZ_CP086482:59341-59402 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References