Detailed information of TA system TA182507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-UPF0150
• Location: 1523907..1524331
• Replicon: chromosome
• Accession: NZ_CP065383
• Organism: Atribacter laminatus strain RT761

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: RT761_RS06955
• Protein ID: WP_218113348.1
• Coordinates: 1524104..1524331 (+)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: RT761_RS06950
• Protein ID: WP_218113347.1
• Coordinates: 1523907..1524107 (+)
• Length: 67 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RT761_RS06930 (RT761_01400)	1520478..1520714	+	237	WP_218113343.1	hypothetical protein	-
RT761_RS06935 (RT761_01401)	1521019..1521936	+	918	WP_218113344.1	VOC family protein	-
RT761_RS06940 (RT761_01402)	1522000..1522434	+	435	WP_218113345.1	ACT domain-containing protein	-
RT761_RS06945	1523140..1523292	-	153	WP_218113346.1	hypothetical protein	-
RT761_RS06950 (RT761_01404)	1523907..1524107	+	201	WP_218113347.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
RT761_RS06955 (RT761_01405)	1524104..1524331	+	228	WP_218113348.1	type II toxin-antitoxin system HicA family toxin	Toxin
RT761_RS06960	1524465..1524680	+	216	Protein_1354	transposase	-
RT761_RS06970 (RT761_01407)	1524978..1525811	-	834	WP_218113350.1	hypothetical protein	-
RT761_RS06975 (RT761_01408)	1525885..1526079	+	195	WP_218113351.1	helix-turn-helix transcriptional regulator	-
RT761_RS06980 (RT761_01409)	1526169..1526534	+	366	WP_218113352.1	hypothetical protein	-
RT761_RS06985 (RT761_01410)	1526531..1527196	+	666	WP_218113353.1	helix-turn-helix domain-containing protein	-
RT761_RS06990 (RT761_01411)	1527625..1528011	+	387	WP_218113354.1	transposase family protein	-
RT761_RS06995 (RT761_01412)	1527998..1528273	+	276	WP_218113355.1	hypothetical protein	-
RT761_RS07000 (RT761_01413)	1528844..1529065	+	222	WP_246465252.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-66)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-49)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8408.09 Da
• Isoelectric Point: 10.6521

>T182507 WP_218113348.1 NZ_CP065383:1524104-1524331 [Atribacter laminatus]
MTPKLPVISGRDCVKALEKIGYKVVRQRGSHLRLKDTNGKLLPVTVPDHKELRPGLVKKILNDANLTVEELIKLL

Nucleotide

• Length: 228 bp

>T182507 NZ_CP086480:c611911-611447 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 67 a.a.
• Molecular weight: 7270.18 Da
• Isoelectric Point: 3.8513

>AT182507 WP_218113347.1 NZ_CP065383:1523907-1524107 [Atribacter laminatus]
VRTYPVIIEQDDTGYVVSCPSFHGCYSQGDTIDEALKNIKEAIELCLDDEEIPIGSVIVGNVVLER

Nucleotide

• Length: 201 bp

>AT182507 NZ_CP086480:c612246-611911 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA