Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1173679..1174244 Replicon chromosome
Accession NZ_CP065382
Organism Faecalibacterium prausnitzii strain Fp944

Toxin (Protein)


Gene name relE Uniprot ID C7H6P5
Locus tag I5P94_RS05685 Protein ID WP_002596328.1
Coordinates 1173954..1174244 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C7H6P4
Locus tag I5P94_RS05680 Protein ID WP_005924829.1
Coordinates 1173679..1173957 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5P94_RS05645 1169574..1169714 - 141 WP_005924798.1 Maff2 family protein -
I5P94_RS05650 1169851..1170669 - 819 Protein_1098 TraG/TraD/VirD4 family protein -
I5P94_RS05655 1170765..1171130 - 366 WP_015528457.1 hypothetical protein -
I5P94_RS05660 1171208..1171402 - 195 WP_002596333.1 transposon-encoded TnpW family protein -
I5P94_RS05665 1171446..1172309 - 864 WP_015528456.1 ATP-binding protein -
I5P94_RS05670 1172306..1173040 - 735 WP_015528455.1 phage replisome organizer N-terminal domain-containing protein -
I5P94_RS05675 1173154..1173552 - 399 WP_015528454.1 cysteine-rich VLP domain-containing protein -
I5P94_RS05680 1173679..1173957 + 279 WP_005924829.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I5P94_RS05685 1173954..1174244 + 291 WP_002596328.1 type II toxin-antitoxin system YafQ family toxin Toxin
I5P94_RS05690 1174322..1175767 - 1446 WP_082424716.1 MobQ family relaxase -
I5P94_RS05695 1175955..1176245 - 291 WP_015524246.1 DUF3847 domain-containing protein -
I5P94_RS05700 1176274..1176735 - 462 WP_015528452.1 sigma-70 family RNA polymerase sigma factor -
I5P94_RS05705 1176746..1177198 - 453 WP_015524244.1 hypothetical protein -
I5P94_RS05710 1177302..1177715 - 414 WP_015524243.1 sigma factor-like helix-turn-helix DNA-binding protein -
I5P94_RS05715 1178185..1178916 - 732 WP_173012942.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(W) - 1085834..1202782 116948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11112.87 Da        Isoelectric Point: 8.0630

>T182506 WP_002596328.1 NZ_CP065382:1173954-1174244 [Faecalibacterium prausnitzii]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T182506 NZ_CP086480:185984-186091 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10247.66 Da        Isoelectric Point: 4.4692

>AT182506 WP_005924829.1 NZ_CP065382:1173679-1173957 [Faecalibacterium prausnitzii]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT182506 NZ_CP086480:c185936-185870 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4XBM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4XB19

References