Detailed information of TA system TA182498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 821004..821549
• Replicon: chromosome
• Accession: NZ_CP065369
• Organism: Vibrio parahaemolyticus strain 20-082A3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: I5M77_RS04235
• Protein ID: WP_025793277.1
• Coordinates: 821004..821300 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q7MKD6
• Locus tag: I5M77_RS04240
• Protein ID: WP_000557294.1
• Coordinates: 821307..821549 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5M77_RS04190	816293..816421	+	129	WP_077672984.1	DUF3265 domain-containing protein	-
I5M77_RS04195	816450..817106	+	657	WP_025793281.1	hypothetical protein	-
I5M77_RS04200	817246..818049	+	804	WP_025793280.1	hypothetical protein	-
I5M77_RS04205	818039..818131	+	93	WP_079725826.1	DUF3265 domain-containing protein	-
I5M77_RS04210	818158..818790	+	633	WP_025793279.1	hypothetical protein	-
I5M77_RS04215	818937..819239	+	303	WP_025537048.1	hypothetical protein	-
I5M77_RS04220	819179..819346	+	168	WP_001883086.1	DUF3265 domain-containing protein	-
I5M77_RS04225	819377..819898	+	522	WP_015296898.1	GNAT family N-acetyltransferase	-
I5M77_RS04230	820028..820366	+	339	WP_196952914.1	cupin domain-containing protein	-
I5M77_RS04235	821004..821300	-	297	WP_025793277.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I5M77_RS04240	821307..821549	-	243	WP_000557294.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I5M77_RS04245	821839..822060	+	222	Protein_840	transposase	-
I5M77_RS04250	822102..822980	+	879	WP_140142865.1	IS3 family transposase	-
I5M77_RS04255	823213..823268	+	56	Protein_842	DUF3265 domain-containing protein	-
I5M77_RS04260	823455..824345	+	891	WP_005485669.1	hypothetical protein	-
I5M77_RS04265	824426..824836	+	411	WP_024701711.1	hypothetical protein	-
I5M77_RS04270	825015..825449	+	435	Protein_845	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	vpadF	778894..856598	77704
	-	flank	IS/Tn	-	-	825817..826203	386
	-	inside	Integron	-	-	780999..825311	44312

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-50)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11249.00 Da
• Isoelectric Point: 9.8450

>T182498 WP_025793277.1 NZ_CP065369:c821300-821004 [Vibrio parahaemolyticus]
MQKNKYKLSKLAQAHLRKIKSYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAILGQSLLPQNHL

Nucleotide

• Length: 297 bp

>T182498 NZ_CP086472:c59297-59148 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8973.13 Da
• Isoelectric Point: 4.6135

>AT182498 WP_000557294.1 NZ_CP065369:c821549-821307 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLRHCFESAKQDLAQGDVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT182498 NZ_CP086472:59341-59402 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Antitoxin

• AlphaFold DB: Q7MKD6