Detailed information of TA system TA182497

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 809315..809862
• Replicon: chromosome
• Accession: NZ_CP065369
• Organism: Vibrio parahaemolyticus strain 20-082A3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I5M77_RS04120
• Protein ID: WP_025793438.1
• Coordinates: 809560..809862 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3A269
• Locus tag: I5M77_RS04115
• Protein ID: WP_005448240.1
• Coordinates: 809315..809572 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5M77_RS04060	804544..804636	+	93	WP_072612521.1	DUF3265 domain-containing protein	-
I5M77_RS04065	805106..805198	+	93	WP_005494820.1	DUF3265 domain-containing protein	-
I5M77_RS04070	805226..805606	+	381	WP_104411071.1	hypothetical protein	-
I5M77_RS04075	805723..806070	+	348	WP_025793492.1	DNA-binding protein	-
I5M77_RS04080	806096..806188	+	93	WP_072606053.1	DUF3265 domain-containing protein	-
I5M77_RS04085	806214..806588	+	375	WP_025793490.1	hypothetical protein	-
I5M77_RS04090	807222..807311	+	90	WP_074190212.1	DUF3265 domain-containing protein	-
I5M77_RS04095	807360..807965	+	606	WP_140142847.1	hypothetical protein	-
I5M77_RS04100	807991..808083	+	93	WP_080259420.1	DUF3265 domain-containing protein	-
I5M77_RS04105	808526..808654	+	129	WP_080277532.1	DUF3265 domain-containing protein	-
I5M77_RS04110	808682..809155	+	474	WP_025534629.1	hypothetical protein	-
I5M77_RS04115	809315..809572	+	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I5M77_RS04120	809560..809862	+	303	WP_025793438.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I5M77_RS04125	810029..810574	+	546	WP_025793483.1	hypothetical protein	-
I5M77_RS04130	810729..811268	+	540	WP_025793484.1	hypothetical protein	-
I5M77_RS04135	811283..811375	+	93	WP_005494856.1	DUF3265 domain-containing protein	-
I5M77_RS04140	811420..811704	+	285	WP_017448465.1	nucleotide pyrophosphohydrolase	-
I5M77_RS04145	811712..811822	+	111	WP_082798391.1	DUF3265 domain-containing protein	-
I5M77_RS04150	811854..812159	+	306	WP_021453216.1	hypothetical protein	-
I5M77_RS04155	812303..812650	+	348	WP_005448158.1	nucleic acid-binding protein	-
I5M77_RS04160	812676..812768	+	93	WP_078235736.1	DUF3265 domain-containing protein	-
I5M77_RS04165	813173..813316	+	144	WP_168937153.1	DUF3265 domain-containing protein	-
I5M77_RS04170	813409..813786	+	378	WP_156216529.1	hypothetical protein	-
I5M77_RS04175	813928..814653	+	726	WP_025793457.1	class I SAM-dependent methyltransferase	-
I5M77_RS04180	814675..814767	+	93	WP_079882702.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	vpadF	778894..856598	77704
	-	inside	Integron	-	-	780999..825311	44312

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11536.51 Da
• Isoelectric Point: 5.8623

>T182497 WP_025793438.1 NZ_CP065369:809560-809862 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQAIFSKVERLVAFPESGRIPPELAHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T182497 NZ_CP086471:68036-68188 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9606.10 Da
• Isoelectric Point: 6.7269

>AT182497 WP_005448240.1 NZ_CP065369:809315-809572 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT182497 NZ_CP086471:c67986-67924 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Antitoxin

• AlphaFold DB: A0A432DGX8