Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 770709..771254 Replicon chromosome
Accession NZ_CP065369
Organism Vibrio parahaemolyticus strain 20-082A3

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag I5M77_RS03770 Protein ID WP_025793418.1
Coordinates 770709..771005 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag I5M77_RS03775 Protein ID WP_023585842.1
Coordinates 771012..771254 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5M77_RS03725 765950..766414 + 465 WP_021485101.1 DUF2846 domain-containing protein -
I5M77_RS03730 766881..767486 + 606 WP_025543333.1 BRCT domain-containing protein -
I5M77_RS03735 767635..768111 + 477 WP_025793422.1 GNAT family N-acetyltransferase -
I5M77_RS03740 768108..768230 + 123 WP_078511351.1 DUF3265 domain-containing protein -
I5M77_RS03745 768266..769012 + 747 WP_025793421.1 hypothetical protein -
I5M77_RS03750 769027..769119 + 93 WP_080277531.1 DUF3265 domain-containing protein -
I5M77_RS03755 769140..769478 + 339 WP_025793420.1 hypothetical protein -
I5M77_RS03760 769637..770044 + 408 WP_025793419.1 OsmC family protein -
I5M77_RS03765 770181..770540 + 360 WP_025555125.1 DUF2750 domain-containing protein -
I5M77_RS03770 770709..771005 - 297 WP_025793418.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I5M77_RS03775 771012..771254 - 243 WP_023585842.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I5M77_RS03780 771381..771458 + 78 WP_080260435.1 DUF3265 domain-containing protein -
I5M77_RS03785 771778..771870 + 93 WP_080252029.1 DUF3265 domain-containing protein -
I5M77_RS03790 772340..772432 + 93 WP_005494820.1 DUF3265 domain-containing protein -
I5M77_RS03795 772526..773380 + 855 WP_025793462.1 AAA family ATPase -
I5M77_RS03800 773373..773759 + 387 WP_025793461.1 hypothetical protein -
I5M77_RS03805 773774..773866 + 93 WP_080277545.1 DUF3265 domain-containing protein -
I5M77_RS03810 774390..774794 + 405 WP_025793460.1 hypothetical protein -
I5M77_RS03815 774936..775475 + 540 WP_005494855.1 hypothetical protein -
I5M77_RS03820 775490..775582 + 93 WP_005494856.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 703024..777684 74660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-54)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11305.96 Da        Isoelectric Point: 9.3813

>T182496 WP_025793418.1 NZ_CP065369:c771005-770709 [Vibrio parahaemolyticus]
MQKNKYKLSKLAQAHLIKIKNYTVNNFSEMQWRNYKDTLLTGFQMLADNPEVGRSCDDIYPNGFHFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Download         Length: 297 bp

>T182496 NZ_CP086471:2255-2533 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8917.15 Da        Isoelectric Point: 5.1006

>AT182496 WP_023585842.1 NZ_CP065369:c771254-771012 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLKHCFESAKKDLAQGNVVDGEDFLSAL

Download         Length: 243 bp

>AT182496 NZ_CP086471:1986-2255 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References