Detailed information of TA system TA182495

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 758730..759289
• Replicon: chromosome
• Accession: NZ_CP065369
• Organism: Vibrio parahaemolyticus strain 20-082A3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I5M77_RS03655
• Protein ID: WP_025793434.1
• Coordinates: 758730..759008 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I5M77_RS03660
• Protein ID: WP_025793433.1
• Coordinates: 759005..759289 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5M77_RS03625	754886..755185	+	300	WP_025793310.1	antibiotic biosynthesis monooxygenase	-
I5M77_RS03630	755402..755779	+	378	WP_086583718.1	hypothetical protein	-
I5M77_RS03635	755895..756380	+	486	WP_148299771.1	hypothetical protein	-
I5M77_RS03640	756517..757017	+	501	WP_025506945.1	hypothetical protein	-
I5M77_RS03645	757708..758586	+	879	WP_025793435.1	hypothetical protein	-
I5M77_RS03650	758609..758701	+	93	WP_079390553.1	DUF3265 domain-containing protein	-
I5M77_RS03655	758730..759008	-	279	WP_025793434.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
I5M77_RS03660	759005..759289	-	285	WP_025793433.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I5M77_RS03665	759569..760093	+	525	WP_025793432.1	hypothetical protein	-
I5M77_RS03670	760452..760544	+	93	WP_193230369.1	DUF3265 domain-containing protein	-
I5M77_RS03675	760573..760974	+	402	WP_025793431.1	DUF2007 domain-containing protein	-
I5M77_RS03680	761127..761522	+	396	WP_025793430.1	hypothetical protein	-
I5M77_RS03685	761658..762037	+	380	Protein_728	energy transducer TonB	-
I5M77_RS03690	762065..762154	+	90	WP_077281740.1	DUF3265 domain-containing protein	-
I5M77_RS03695	762182..762658	+	477	WP_025793429.1	GNAT family N-acetyltransferase	-
I5M77_RS03700	762667..762777	+	111	WP_079757379.1	DUF3265 domain-containing protein	-
I5M77_RS03705	762807..763340	+	534	WP_025793428.1	cysteine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	703024..777684	74660

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10893.59 Da
• Isoelectric Point: 4.4442

>T182495 WP_025793434.1 NZ_CP065369:c759008-758730 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIDVKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISHWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T182495 NZ_CP086470:c4346312-4346139 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11039.37 Da
• Isoelectric Point: 9.2167

>AT182495 WP_025793433.1 NZ_CP065369:c759289-759005 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT182495 NZ_CP086470:c4346636-4346340 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG