Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE(toxin) |
| Location | 717435..717994 | Replicon | chromosome |
| Accession | NZ_CP065369 | ||
| Organism | Vibrio parahaemolyticus strain 20-082A3 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | I5M77_RS03280 | Protein ID | WP_025793444.1 |
| Coordinates | 717435..717713 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U2ZGZ5 |
| Locus tag | I5M77_RS03285 | Protein ID | WP_005497249.1 |
| Coordinates | 717710..717994 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I5M77_RS03225 | 712585..712956 | + | 372 | WP_025793440.1 | RidA family protein | - |
| I5M77_RS03230 | 712953..713093 | + | 141 | WP_148299773.1 | DUF3265 domain-containing protein | - |
| I5M77_RS03235 | 713102..713764 | + | 663 | WP_025793441.1 | hypothetical protein | - |
| I5M77_RS03240 | 713785..713877 | + | 93 | WP_080277533.1 | DUF3265 domain-containing protein | - |
| I5M77_RS03245 | 713911..714285 | + | 375 | WP_025793442.1 | hypothetical protein | - |
| I5M77_RS03250 | 714272..714391 | + | 120 | WP_080277534.1 | DUF3265 domain-containing protein | - |
| I5M77_RS03255 | 714475..714840 | + | 366 | WP_025793443.1 | hypothetical protein | - |
| I5M77_RS03260 | 715327..715419 | + | 93 | WP_140050476.1 | DUF3265 domain-containing protein | - |
| I5M77_RS03265 | 716516..716647 | + | 132 | WP_080277536.1 | DUF3265 domain-containing protein | - |
| I5M77_RS03270 | 716729..716986 | + | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| I5M77_RS03275 | 716974..717276 | + | 303 | WP_025548916.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| I5M77_RS03280 | 717435..717713 | - | 279 | WP_025793444.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| I5M77_RS03285 | 717710..717994 | - | 285 | WP_005497249.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| I5M77_RS03290 | 719330..719752 | + | 423 | Protein_649 | GFA family protein | - |
| I5M77_RS03295 | 719786..719875 | + | 90 | WP_077281693.1 | DUF3265 domain-containing protein | - |
| I5M77_RS03300 | 720464..720766 | - | 303 | WP_025793446.1 | hypothetical protein | - |
| I5M77_RS03305 | 720840..720932 | + | 93 | WP_080261757.1 | DUF3265 domain-containing protein | - |
| I5M77_RS03310 | 720974..721240 | + | 267 | WP_025793447.1 | barstar family protein | - |
| I5M77_RS03315 | 721418..722020 | + | 603 | WP_033904997.1 | hypothetical protein | - |
| I5M77_RS03320 | 722138..722875 | + | 738 | WP_025793449.1 | hypothetical protein | - |
| I5M77_RS03325 | 722904..722981 | + | 78 | WP_080277538.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 703024..777684 | 74660 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10930.57 Da Isoelectric Point: 4.3697
>T182494 WP_025793444.1 NZ_CP065369:c717713-717435 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPEAADKTDDIIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRIM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPEAADKTDDIIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRIM
RVLHQKQKFPTD
Download Length: 279 bp
>T182494 NZ_CP086470:c4244143-4243793 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10913.25 Da Isoelectric Point: 9.1865
>AT182494 WP_005497249.1 NZ_CP065369:c717994-717710 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL
Download Length: 285 bp
>AT182494 NZ_CP086470:c4244388-4244137 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|