Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 716729..717276 Replicon chromosome
Accession NZ_CP065369
Organism Vibrio parahaemolyticus strain 20-082A3

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR19
Locus tag I5M77_RS03275 Protein ID WP_025548916.1
Coordinates 716974..717276 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag I5M77_RS03270 Protein ID WP_005448240.1
Coordinates 716729..716986 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5M77_RS03220 711752..712471 + 720 WP_025793439.1 hypothetical protein -
I5M77_RS03225 712585..712956 + 372 WP_025793440.1 RidA family protein -
I5M77_RS03230 712953..713093 + 141 WP_148299773.1 DUF3265 domain-containing protein -
I5M77_RS03235 713102..713764 + 663 WP_025793441.1 hypothetical protein -
I5M77_RS03240 713785..713877 + 93 WP_080277533.1 DUF3265 domain-containing protein -
I5M77_RS03245 713911..714285 + 375 WP_025793442.1 hypothetical protein -
I5M77_RS03250 714272..714391 + 120 WP_080277534.1 DUF3265 domain-containing protein -
I5M77_RS03255 714475..714840 + 366 WP_025793443.1 hypothetical protein -
I5M77_RS03260 715327..715419 + 93 WP_140050476.1 DUF3265 domain-containing protein -
I5M77_RS03265 716516..716647 + 132 WP_080277536.1 DUF3265 domain-containing protein -
I5M77_RS03270 716729..716986 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I5M77_RS03275 716974..717276 + 303 WP_025548916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I5M77_RS03280 717435..717713 - 279 WP_025793444.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
I5M77_RS03285 717710..717994 - 285 WP_005497249.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
I5M77_RS03290 719330..719752 + 423 Protein_649 GFA family protein -
I5M77_RS03295 719786..719875 + 90 WP_077281693.1 DUF3265 domain-containing protein -
I5M77_RS03300 720464..720766 - 303 WP_025793446.1 hypothetical protein -
I5M77_RS03305 720840..720932 + 93 WP_080261757.1 DUF3265 domain-containing protein -
I5M77_RS03310 720974..721240 + 267 WP_025793447.1 barstar family protein -
I5M77_RS03315 721418..722020 + 603 WP_033904997.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 703024..777684 74660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11669.57 Da        Isoelectric Point: 5.1765

>T182493 WP_025548916.1 NZ_CP065369:716974-717276 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T182493 NZ_CP086470:c4128044-4127757 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT182493 WP_005448240.1 NZ_CP065369:716729-716986 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT182493 NZ_CP086470:c4127770-4127468 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR19

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References