Detailed information of TA system TA182491

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 209695..210223
• Replicon: chromosome
• Accession: NZ_CP065367
• Organism: Vibrio cyclitrophicus strain ED287

Toxin (Protein)

• Gene name: relE
• Uniprot ID: K5TRR0
• Locus tag: ITG09_RS16825
• Protein ID: WP_005377002.1
• Coordinates: 209695..209985 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ITG09_RS16830
• Protein ID: WP_248376157.1
• Coordinates: 209975..210223 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ITG09_RS16800 (ITG09_16780)	206036..206632	+	597	WP_248376154.1	hypothetical protein	-
ITG09_RS16805 (ITG09_16785)	206973..207449	+	477	WP_248376155.1	GNAT family N-acetyltransferase	-
ITG09_RS16810 (ITG09_16790)	207908..209145	+	1238	WP_248373810.1	IS3 family transposase	-
ITG09_RS16815 (ITG09_16795)	209276..209569	+	294	WP_248376156.1	hypothetical protein	-
ITG09_RS16820 (ITG09_16800)	209584..209676	+	93	WP_074531713.1	DUF3265 domain-containing protein	-
ITG09_RS16825 (ITG09_16805)	209695..209985	-	291	WP_005377002.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ITG09_RS16830 (ITG09_16810)	209975..210223	-	249	WP_248376157.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ITG09_RS16835 (ITG09_16815)	210298..210366	+	69	WP_077672877.1	DUF3265 domain-containing protein	-
ITG09_RS16840 (ITG09_16820)	210416..211090	+	675	WP_248376158.1	hypothetical protein	-
ITG09_RS16845 (ITG09_16825)	211446..212125	-	680	Protein_181	IS110 family transposase	-
ITG09_RS16850 (ITG09_16830)	212220..212849	+	630	WP_017632997.1	hypothetical protein	-
ITG09_RS16855 (ITG09_16835)	212991..213593	+	603	WP_248376159.1	DUF922 domain-containing protein	-
ITG09_RS16860 (ITG09_16840)	213743..214225	+	483	WP_248376160.1	MazG-related protein	-
ITG09_RS16865 (ITG09_16845)	214282..214680	-	399	WP_248376161.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	207908..212125	4217
	-	inside	Integron	-	-	206973..211090	4117

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11261.25 Da
• Isoelectric Point: 10.5932

>T182491 WP_005377002.1 NZ_CP065367:c209985-209695 [Vibrio cyclitrophicus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T182491 NZ_CP086470:c3786646-3786248 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9079.37 Da
• Isoelectric Point: 3.9610

>AT182491 WP_248376157.1 NZ_CP065367:c210223-209975 [Vibrio cyclitrophicus]
MTARILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLTIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT182491 NZ_CP086470:c3786942-3786649 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A347UR03