Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1502969..1503497 Replicon chromosome
Accession NZ_CP065366
Organism Vibrio cyclitrophicus strain ED287

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ITG09_RS06755 Protein ID WP_248374586.1
Coordinates 1502969..1503259 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID K5UYY9
Locus tag ITG09_RS06760 Protein ID WP_004730320.1
Coordinates 1503249..1503497 (-) Length 83 a.a.

Genomic Context

ITG09_RS06730ITG09_RS06735ITG09_RS06740ITG09_RS06765ITG09_RS06770ITG09_RS06775ITG09_RS06785ITG09_RS06745ITG09_RS06750ITG09_RS06755ITG09_RS06760ITG09_RS06780ITG09_RS06790
Location: 1497990..1498967 (978 bp)
Type: Others
Protein ID: WP_248374582.1
Location: 1498968..1499111 (144 bp)
Type: Others
Protein ID: WP_248374583.1
Location: 1499593..1499892 (300 bp)
Type: Others
Protein ID: WP_248374584.1
Location: 1503572..1503640 (69 bp)
Type: Others
Protein ID: WP_077672877.1
Location: 1503705..1504514 (810 bp)
Type: Others
Protein ID: WP_248374587.1
Location: 1504672..1504980 (309 bp)
Type: Others
Protein ID: WP_248374588.1
Location: 1506473..1507459 (987 bp)
Type: Others
Protein ID: WP_248374590.1
Location: 1500385..1501344 (960 bp)
Type: Others
Protein ID: WP_248374585.1
Location: 1501772..1502745 (974 bp)
Type: Others
Protein ID: Protein_1261
Location: 1502969..1503259 (291 bp)
Type: Toxin
Protein ID: WP_248374586.1
Location: 1503249..1503497 (249 bp)
Type: Antitoxin
Protein ID: WP_004730320.1
Location: 1505346..1506374 (1029 bp)
Type: Others
Protein ID: WP_248374589.1
Location: 1507496..1508452 (957 bp)
Type: Others
Protein ID: WP_248374591.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ITG09_RS06730 (ITG09_06730)1497990..1498967+978WP_248374582.1LysR family transcriptional regulator-
ITG09_RS06735 (ITG09_06735)1498968..1499111+144WP_248374583.1DeoR family transcriptional regulator-
ITG09_RS06740 (ITG09_06740)1499593..1499892+300WP_248374584.1hypothetical protein-
ITG09_RS06745 (ITG09_06745)1500385..1501344-960WP_248374585.1nuclease-related domain-containing protein-
ITG09_RS06750 (ITG09_06750)1501772..1502745-974Protein_1261integron integrase-
ITG09_RS06755 (ITG09_06755)1502969..1503259-291WP_248374586.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ITG09_RS06760 (ITG09_06760)1503249..1503497-249WP_004730320.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ITG09_RS06765 (ITG09_06765)1503572..1503640+69WP_077672877.1DUF3265 domain-containing protein-
ITG09_RS06770 (ITG09_06770)1503705..1504514+810WP_248374587.1DUF2971 domain-containing protein-
ITG09_RS06775 (ITG09_06775)1504672..1504980+309WP_248374588.1hypothetical protein-
ITG09_RS06780 (ITG09_06780)1505346..1506374-1029WP_248374589.1IS110 family transposase-
ITG09_RS06785 (ITG09_06785)1506473..1507459+987WP_248374590.1nucleotide-binding protein-
ITG09_RS06790 (ITG09_06790)1507496..1508452-957WP_248374591.1IS110 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1488227..151582227595
-insideIntegron--1501984..15049802996


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11289.26 Da        Isoelectric Point: 10.6284

>T182490 WP_248374586.1 NZ_CP065366:c1503259-1502969 [Vibrio cyclitrophicus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYRVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T182490 NZ_CP086470:3574017-3574235 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9109.39 Da        Isoelectric Point: 3.9610

>AT182490 WP_004730320.1 NZ_CP065366:c1503497-1503249 [Vibrio cyclitrophicus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLTIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT182490 NZ_CP086470:3573617-3573991 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0L1LA33

References