Detailed information of TA system TA182490

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1502969..1503497
• Replicon: chromosome
• Accession: NZ_CP065366
• Organism: Vibrio cyclitrophicus strain ED287

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ITG09_RS06755
• Protein ID: WP_248374586.1
• Coordinates: 1502969..1503259 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: K5UYY9
• Locus tag: ITG09_RS06760
• Protein ID: WP_004730320.1
• Coordinates: 1503249..1503497 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ITG09_RS06730 (ITG09_06730)	1497990..1498967	+	978	WP_248374582.1	LysR family transcriptional regulator	-
ITG09_RS06735 (ITG09_06735)	1498968..1499111	+	144	WP_248374583.1	DeoR family transcriptional regulator	-
ITG09_RS06740 (ITG09_06740)	1499593..1499892	+	300	WP_248374584.1	hypothetical protein	-
ITG09_RS06745 (ITG09_06745)	1500385..1501344	-	960	WP_248374585.1	nuclease-related domain-containing protein	-
ITG09_RS06750 (ITG09_06750)	1501772..1502745	-	974	Protein_1261	integron integrase	-
ITG09_RS06755 (ITG09_06755)	1502969..1503259	-	291	WP_248374586.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ITG09_RS06760 (ITG09_06760)	1503249..1503497	-	249	WP_004730320.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ITG09_RS06765 (ITG09_06765)	1503572..1503640	+	69	WP_077672877.1	DUF3265 domain-containing protein	-
ITG09_RS06770 (ITG09_06770)	1503705..1504514	+	810	WP_248374587.1	DUF2971 domain-containing protein	-
ITG09_RS06775 (ITG09_06775)	1504672..1504980	+	309	WP_248374588.1	hypothetical protein	-
ITG09_RS06780 (ITG09_06780)	1505346..1506374	-	1029	WP_248374589.1	IS110 family transposase	-
ITG09_RS06785 (ITG09_06785)	1506473..1507459	+	987	WP_248374590.1	nucleotide-binding protein	-
ITG09_RS06790 (ITG09_06790)	1507496..1508452	-	957	WP_248374591.1	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1488227..1515822	27595
	-	inside	Integron	-	-	1501984..1504980	2996

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11289.26 Da
• Isoelectric Point: 10.6284

>T182490 WP_248374586.1 NZ_CP065366:c1503259-1502969 [Vibrio cyclitrophicus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYRVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T182490 NZ_CP086470:3574017-3574235 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9109.39 Da
• Isoelectric Point: 3.9610

>AT182490 WP_004730320.1 NZ_CP065366:c1503497-1503249 [Vibrio cyclitrophicus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLTIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT182490 NZ_CP086470:3573617-3573991 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A0L1LA33