Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 7544..8087 Replicon plasmid unnamed2
Accession NZ_CP065361
Organism Ruegeria sp. SCSIO 43209

Toxin (Protein)


Gene name parE Uniprot ID A0A521F637
Locus tag I5192_RS19245 Protein ID WP_009827038.1
Coordinates 7544..7843 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A521F6B6
Locus tag I5192_RS19250 Protein ID WP_009827037.1
Coordinates 7836..8087 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5192_RS19240 (I5192_19225) 3021..7417 - 4397 Protein_3 strawberry notch family protein -
I5192_RS19245 (I5192_19230) 7544..7843 - 300 WP_009827038.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I5192_RS19250 (I5192_19235) 7836..8087 - 252 WP_009827037.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
I5192_RS19255 (I5192_19240) 8209..8781 - 573 WP_223118426.1 hypothetical protein -
I5192_RS19260 (I5192_19245) 8887..9363 - 477 WP_009827035.1 hypothetical protein -
I5192_RS19265 (I5192_19250) 9365..9748 - 384 WP_009827034.1 hypothetical protein -
I5192_RS19270 (I5192_19255) 9827..10123 - 297 WP_223118427.1 hypothetical protein -
I5192_RS19275 (I5192_19260) 10240..10620 - 381 WP_009827032.1 DUF3768 domain-containing protein -
I5192_RS22595 10747..11634 - 888 WP_255612204.1 hypothetical protein -
I5192_RS22600 11631..12917 - 1287 WP_255612205.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..66678 66678


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-91)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11409.91 Da        Isoelectric Point: 6.3235

>T182489 WP_009827038.1 NZ_CP065361:c7843-7544 [Ruegeria sp. SCSIO 43209]
MRDIHHSQAAKSDLVDIWVETDRQWGEAQADRYLDDIDRALKGLIANPQMGSDCSDLLQGARKLITGRHLVFYEVDPDRI
FVIRVLHQSMDVPRHLRSS

Download         Length: 300 bp

>T182489 NZ_CP086470:2755702-2755809 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9139.30 Da        Isoelectric Point: 5.1299

>AT182489 WP_009827037.1 NZ_CP065361:c8087-7836 [Ruegeria sp. SCSIO 43209]
MASTSVTLGPHWDEFIALMLKEGRYGSTSELIRASLRLMEEQEGQRARLRVALMEGKQSGDAGPLDMDEIKRDARSRSGA
SDA

Download         Length: 252 bp

>AT182489 NZ_CP086470:c2755655-2755589 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A521F637

Antitoxin

Source ID Structure
AlphaFold DB A0A521F6B6

References