182466

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1849885..1850661 Replicon chromosome
Accession NZ_CP065355
Organism Staphylococcus aureus strain JW31330_O1_dhc

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag I5046_RS08740 Protein ID WP_000031108.1
Coordinates 1849885..1850037 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag I5046_RS08745 Protein ID WP_001251218.1
Coordinates 1850062..1850661 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5046_RS08725 (I5046_08725) 1845965..1846786 + 822 WP_000669380.1 RluA family pseudouridine synthase -
I5046_RS08730 (I5046_08730) 1847246..1848631 - 1386 WP_000116235.1 class II fumarate hydratase -
I5046_RS08735 (I5046_08735) 1848827..1849222 - 396 WP_000901022.1 hypothetical protein -
I5046_RS08740 (I5046_08740) 1849885..1850037 - 153 WP_000031108.1 SAS053 family protein Toxin
I5046_RS08745 (I5046_08745) 1850062..1850661 - 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
I5046_RS08750 (I5046_08750) 1850820..1851290 - 471 WP_123138777.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
I5046_RS08755 (I5046_08755) 1851295..1852422 - 1128 WP_000379982.1 tRNA epoxyqueuosine(34) reductase QueG -
I5046_RS08760 (I5046_08760) 1852573..1853295 - 723 WP_196957479.1 amino acid ABC transporter ATP-binding protein -
I5046_RS08765 (I5046_08765) 1853288..1854745 - 1458 WP_000649919.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T182466 WP_000031108.1 NZ_CP065355:c1850037-1849885 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T182466 NZ_CP086467:c2555446-2555129 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT182466 WP_001251218.1 NZ_CP065355:c1850661-1850062 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT182466 NZ_CP086467:c2555053-2554757 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCTGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCACCCAACCGGTGCAGCCAGAAAG
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References