Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1902211..1902987 Replicon chromosome
Accession NZ_CP065354
Organism Staphylococcus aureus strain JW_comp_novo

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag I5044_RS09120 Protein ID WP_000031108.1
Coordinates 1902211..1902363 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag I5044_RS09125 Protein ID WP_001251218.1
Coordinates 1902388..1902987 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5044_RS09105 (I5044_09105) 1898291..1899112 + 822 WP_000669380.1 RluA family pseudouridine synthase -
I5044_RS09110 (I5044_09110) 1899572..1900957 - 1386 WP_000116235.1 class II fumarate hydratase -
I5044_RS09115 (I5044_09115) 1901153..1901548 - 396 WP_000901022.1 hypothetical protein -
I5044_RS09120 (I5044_09120) 1902211..1902363 - 153 WP_000031108.1 SAS053 family protein Toxin
I5044_RS09125 (I5044_09125) 1902388..1902987 - 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
I5044_RS09130 (I5044_09130) 1903146..1903616 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
I5044_RS09135 (I5044_09135) 1903621..1904748 - 1128 WP_000379982.1 tRNA epoxyqueuosine(34) reductase QueG -
I5044_RS09140 (I5044_09140) 1904899..1905621 - 723 WP_196957479.1 amino acid ABC transporter ATP-binding protein -
I5044_RS09145 (I5044_09145) 1905614..1907071 - 1458 WP_000649919.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T182457 WP_000031108.1 NZ_CP065354:c1902363-1902211 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T182457 NZ_CP086464:c4797407-4797066 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGTCTGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAAGGGATTC
AACTGGCAAGAACACTCCCCATATCTGCGGGCAGTTGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGCGCCGAAG
CCGTAAAAATGCTGTACGTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT182457 WP_001251218.1 NZ_CP065354:c1902987-1902388 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT182457 NZ_CP086464:c4797769-4797428 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGAATTCAGCAACGCAGAATCTT
TGAAGTTGGATGAGGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTTTTTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References