Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1849848..1850624 Replicon chromosome
Accession NZ_CP065353
Organism Staphylococcus aureus strain AR39_O1_merpol

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag I5043_RS08735 Protein ID WP_000031108.1
Coordinates 1849848..1850000 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag I5043_RS08740 Protein ID WP_001251219.1
Coordinates 1850025..1850624 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5043_RS08715 (I5043_08715) 1845856..1846677 + 822 WP_000669385.1 RluA family pseudouridine synthase -
I5043_RS08720 (I5043_08720) 1847128..1848513 - 1386 WP_196931728.1 class II fumarate hydratase -
I5043_RS08725 (I5043_08725) 1848709..1849104 - 396 WP_000901023.1 hypothetical protein -
I5043_RS08730 (I5043_08730) 1849325..1849462 + 138 WP_162634120.1 hypothetical protein -
I5043_RS08735 (I5043_08735) 1849848..1850000 - 153 WP_000031108.1 SAS053 family protein Toxin
I5043_RS08740 (I5043_08740) 1850025..1850624 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
I5043_RS08745 (I5043_08745) 1850783..1851253 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
I5043_RS08750 (I5043_08750) 1851258..1852385 - 1128 WP_000379979.1 tRNA epoxyqueuosine(34) reductase QueG -
I5043_RS08755 (I5043_08755) 1852536..1853258 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
I5043_RS08760 (I5043_08760) 1853251..1854708 - 1458 WP_000649892.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T182445 WP_000031108.1 NZ_CP065353:c1850000-1849848 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T182445 NZ_CP086461:c4890089-4889805 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT182445 WP_001251219.1 NZ_CP065353:c1850624-1850025 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT182445 NZ_CP086461:c4890321-4890079 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGGTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References