Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4799999..4800515 Replicon chromosome
Accession NZ_CP065341
Organism Klebsiella pneumoniae strain ZG2017CW 1-1-1

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag I5Q76_RS23515 Protein ID WP_009486548.1
Coordinates 4799999..4800283 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I5Q76_RS23520 Protein ID WP_002886901.1
Coordinates 4800273..4800515 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5Q76_RS23490 4795416..4795724 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
I5Q76_RS23495 4795809..4795982 + 174 WP_002886906.1 hypothetical protein -
I5Q76_RS23500 4795985..4796728 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I5Q76_RS23505 4797085..4799223 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
I5Q76_RS23510 4799531..4799995 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I5Q76_RS23515 4799999..4800283 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I5Q76_RS23520 4800273..4800515 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I5Q76_RS23525 4800593..4802503 - 1911 WP_009486549.1 BglG family transcription antiterminator -
I5Q76_RS23530 4802526..4803680 - 1155 WP_020316350.1 lactonase family protein -
I5Q76_RS23535 4803747..4804487 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T182383 WP_009486548.1 NZ_CP065341:c4800283-4799999 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T182383 NZ_CP086434:c21248-20832 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT182383 WP_002886901.1 NZ_CP065341:c4800515-4800273 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT182383 NZ_CP086434:c21475-21245 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References