Detailed information of TA system TA182353

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataT-tacA/GNAT-DUF1778
• Location: 1101256..1102019
• Replicon: chromosome
• Accession: NZ_CP065276
• Organism: Mycobacteroides abscessus subsp. abscessus strain GD54

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: U5X3E3
• Locus tag: I3U41_RS05410
• Protein ID: WP_023363547.1
• Coordinates: 1101256..1101753 (-)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: I3U41_RS05415
• Protein ID: WP_053082894.1
• Coordinates: 1101750..1102019 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I3U41_RS05390	1097867..1098499	+	633	WP_023363553.1	class I SAM-dependent methyltransferase	-
I3U41_RS05395	1098689..1099285	-	597	WP_023363551.1	ABATE domain-containing protein	-
I3U41_RS05400	1099386..1099955	+	570	WP_023363549.1	TIGR03086 family protein	-
I3U41_RS05405	1099991..1100860	+	870	WP_052622775.1	pyridoxamine 5'-phosphate oxidase family protein	-
I3U41_RS05410	1101256..1101753	-	498	WP_023363547.1	GNAT family N-acetyltransferase	Toxin
I3U41_RS05415	1101750..1102019	-	270	WP_053082894.1	DUF1778 domain-containing protein	Antitoxin
I3U41_RS05420	1102471..1102944	+	474	WP_005082966.1	MarR family transcriptional regulator	-
I3U41_RS05425	1102952..1104367	+	1416	WP_005113402.1	membrane protein	-
I3U41_RS05430	1104372..1105466	-	1095	WP_025089030.1	DUF2236 domain-containing protein	-
I3U41_RS05435	1105553..1106155	+	603	WP_005113405.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (43-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (9-82)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18258.94 Da
• Isoelectric Point: 9.5209

>T182353 WP_023363547.1 NZ_CP065276:c1101753-1101256 [Mycobacteroides abscessus subsp. abscessus]
VSYEGPVLFGADHIVDDFDCGNDVLNEWLRTKALHNQREGGSRTWVVLDGRRVVAFYASSTAVLMRSRATKRAARNQPDP
LPAVLLGRLAVDANHQGRGLAAALLKHFILKSLEVAELTGVRLLLVHANNDTARRFYLRYGFEPSPVDDLTLMLLVKDVR
PSPSA

Nucleotide

• Length: 498 bp

>T182353 NZ_CP086416:c5069356-5068439 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9925.25 Da
• Isoelectric Point: 5.6845

>AT182353 WP_053082894.1 NZ_CP065276:c1102019-1101750 [Mycobacteroides abscessus subsp. abscessus]
VETKSGRWHLRVTAAQDAVVRRVLDVTGESLNDYVVRHAVQAAEADLADRRVFVLDDAAWTDLQALLDRPPSPKPELARL
LANPSILER

Nucleotide

• Length: 270 bp

>AT182353 NZ_CP086416:c5070120-5069362 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGAGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A8B4DM98