Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 4461168..4461733 Replicon chromosome
Accession NZ_CP065255
Organism Streptomyces clavuligerus strain F1D10

Toxin (Protein)


Gene name doc Uniprot ID E2Q583
Locus tag I3J07_RS18355 Protein ID WP_003960643.1
Coordinates 4461365..4461733 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag I3J07_RS18350 Protein ID WP_029182939.1
Coordinates 4461168..4461365 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3J07_RS18335 4458555..4459118 + 564 WP_003954788.1 AAA family ATPase -
I3J07_RS18345 4459629..4461134 + 1506 WP_003954790.1 MFS transporter -
I3J07_RS18350 4461168..4461365 + 198 WP_029182939.1 Arc family DNA-binding protein Antitoxin
I3J07_RS18355 4461365..4461733 + 369 WP_003960643.1 Fic family protein Toxin
I3J07_RS18360 4461891..4463684 + 1794 WP_003954793.1 DEAD/DEAH box helicase -
I3J07_RS18365 4463986..4464627 + 642 WP_009996313.1 helix-turn-helix domain-containing protein -
I3J07_RS18370 4465092..4465880 + 789 WP_065757152.1 hypothetical protein -
I3J07_RS18375 4465945..4466415 - 471 WP_003954796.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(19-119)

Antitoxin

Arc-like DNA binding domain

(5-29)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13688.61 Da        Isoelectric Point: 5.1348

>T182348 WP_003960643.1 NZ_CP065255:4461365-4461733 [Streptomyces clavuligerus]
MHYLTLPELLNLAERLRAAEVRDYGLLDSALARPQASVFGQDAYPDVWQKAAALMESLARNHGLVDGNKRIAWYATWVFL
HVNGHPLDPEFDVDEAERFVLDVCQGALDVPKIASGLLRFAR

Download         Length: 369 bp

>T182348 NZ_CP086416:2073247-2073349 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7424.32 Da        Isoelectric Point: 5.7030

>AT182348 WP_029182939.1 NZ_CP065255:4461168-4461365 [Streptomyces clavuligerus]
MAGLNVRFTEEELTALRERAEAEGRSMQSFAHDAVIRAINERARLFNEAAEHVLRASEELNRRLA

Download         Length: 198 bp

>AT182348 NZ_CP086416:c2073356-2073211 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2Q583

Antitoxin

Source ID Structure

References