Detailed information of TA system TA182341

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 4449311..4449876
• Replicon: chromosome
• Accession: NZ_CP065234
• Organism: Streptomyces clavuligerus strain F1D18

Toxin (Protein)

• Gene name: doc
• Uniprot ID: E2Q583
• Locus tag: I3J09_RS18315
• Protein ID: WP_003960643.1
• Coordinates: 4449508..4449876 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: I3J09_RS18310
• Protein ID: WP_029182939.1
• Coordinates: 4449311..4449508 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I3J09_RS18295	4446698..4447261	+	564	WP_003954788.1	AAA family ATPase	-
I3J09_RS18305	4447772..4449277	+	1506	WP_003954790.1	MFS transporter	-
I3J09_RS18310	4449311..4449508	+	198	WP_029182939.1	Arc family DNA-binding protein	Antitoxin
I3J09_RS18315	4449508..4449876	+	369	WP_003960643.1	Fic family protein	Toxin
I3J09_RS18320	4450034..4451827	+	1794	WP_003954793.1	DEAD/DEAH box helicase	-
I3J09_RS18325	4452129..4452770	+	642	WP_009996313.1	helix-turn-helix domain-containing protein	-
I3J09_RS18330	4453235..4454023	+	789	WP_065757152.1	hypothetical protein	-
I3J09_RS18335	4454088..4454558	-	471	WP_003954796.1	Lrp/AsnC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (19-119)

Antitoxin

• Arc-like DNA binding domain (5-29)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13688.61 Da
• Isoelectric Point: 5.1348

>T182341 WP_003960643.1 NZ_CP065234:4449508-4449876 [Streptomyces clavuligerus]
MHYLTLPELLNLAERLRAAEVRDYGLLDSALARPQASVFGQDAYPDVWQKAAALMESLARNHGLVDGNKRIAWYATWVFL
HVNGHPLDPEFDVDEAERFVLDVCQGALDVPKIASGLLRFAR

Nucleotide

• Length: 369 bp

>T182341 NZ_CP086411:2888310-2888453 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7424.32 Da
• Isoelectric Point: 5.7030

>AT182341 WP_029182939.1 NZ_CP065234:4449311-4449508 [Streptomyces clavuligerus]
MAGLNVRFTEEELTALRERAEAEGRSMQSFAHDAVIRAINERARLFNEAAEHVLRASEELNRRLA

Nucleotide

• Length: 198 bp

>AT182341 NZ_CP086411:c2888213-2888012 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: E2Q583