Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2568657..2569275 Replicon chromosome
Accession NZ_CP065232
Organism Thalassospira sp. B30-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A1B9VLU3
Locus tag IT971_RS12440 Protein ID WP_063095807.1
Coordinates 2568657..2568845 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1B9VLZ2
Locus tag IT971_RS12445 Protein ID WP_063095805.1
Coordinates 2568907..2569275 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT971_RS12410 2564024..2564500 + 477 WP_063095815.1 hypothetical protein -
IT971_RS12415 2564561..2565457 - 897 WP_063095813.1 SDR family oxidoreductase -
IT971_RS12420 2565582..2566532 + 951 WP_063095811.1 AraC family transcriptional regulator -
IT971_RS12425 2566549..2567004 - 456 WP_063095809.1 GNAT family N-acetyltransferase -
IT971_RS12430 2567004..2568323 - 1320 WP_110252640.1 diguanylate cyclase -
IT971_RS12435 2568451..2568540 + 90 WP_196871062.1 AraC family transcriptional regulator -
IT971_RS12440 2568657..2568845 + 189 WP_063095807.1 type II toxin-antitoxin system HicA family toxin Toxin
IT971_RS12445 2568907..2569275 + 369 WP_063095805.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IT971_RS12450 2569492..2570601 + 1110 WP_082822718.1 DUF4238 domain-containing protein -
IT971_RS12455 2570817..2571029 + 213 WP_063095801.1 type II toxin-antitoxin system HicA family toxin -
IT971_RS12460 2571069..2571494 + 426 WP_063095798.1 type II toxin-antitoxin system HicB family antitoxin -
IT971_RS12465 2571676..2572851 + 1176 WP_063095796.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(8-118)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6931.12 Da        Isoelectric Point: 11.0775

>T182335 WP_063095807.1 NZ_CP065232:2568657-2568845 [Thalassospira sp. B30-1]
MDSKTILKRLQADGWEIVRTKGSHHQLSHPTKPGKVTVPHPKRDLPIGTVKNIEKQSGVKLL

Download         Length: 189 bp

>T182335 NZ_CP086411:c2733665-2733564 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 12914.75 Da        Isoelectric Point: 4.6972

>AT182335 WP_063095805.1 NZ_CP065232:2568907-2569275 [Thalassospira sp. B30-1]
MKQTYWGLVHKDGGSDFGISFPDFPGCVSAASSMTELVEMGTEALTLHIDGMHEDGEPIPAPSPMVELPKDADGIVAITV
AVPGKKRRINLTIDANLIDQIEAKHGKGAVSGFLEDAARKAL

Download         Length: 369 bp

>AT182335 NZ_CP086411:2733440-2733619 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B9VLU3

Antitoxin

Source ID Structure
AlphaFold DB A0A1B9VLZ2

References