Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 2449037..2449571 Replicon chromosome
Accession NZ_CP065232
Organism Thalassospira sp. B30-1

Toxin (Protein)


Gene name relE Uniprot ID A0A1B9VLJ2
Locus tag IT971_RS11890 Protein ID WP_063091832.1
Coordinates 2449037..2449318 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A1B9VLJ5
Locus tag IT971_RS11895 Protein ID WP_063091831.1
Coordinates 2449305..2449571 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT971_RS11860 2444223..2445200 - 978 WP_063091836.1 AraC family transcriptional regulator -
IT971_RS11865 2445325..2446533 + 1209 WP_063091835.1 MFS transporter -
IT971_RS11870 2446753..2447547 + 795 WP_065702010.1 PRC-barrel domain-containing protein -
IT971_RS11875 2447755..2448321 + 567 WP_063091834.1 lipid-binding SYLF domain-containing protein -
IT971_RS11880 2448362..2448709 + 348 WP_063091833.1 HPF/RaiA family ribosome-associated protein -
IT971_RS11885 2448792..2448965 - 174 WP_175494879.1 hypothetical protein -
IT971_RS11890 2449037..2449318 - 282 WP_063091832.1 type II toxin-antitoxin system YafQ family toxin Toxin
IT971_RS11895 2449305..2449571 - 267 WP_063091831.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IT971_RS11900 2449871..2450167 - 297 WP_063091830.1 hypothetical protein -
IT971_RS11905 2450260..2452080 - 1821 WP_063091829.1 ATP-dependent helicase -
IT971_RS11910 2452067..2453944 - 1878 WP_063091828.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-81)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10953.48 Da        Isoelectric Point: 8.0900

>T182334 WP_063091832.1 NZ_CP065232:c2449318-2449037 [Thalassospira sp. B30-1]
MRTIEYSTRFKRDYKREAKGRFRSDIDAILMPVLEDLVADKPLDAQYHDHDLSGNWRGYRECHLKPDLLLIHRKDGADIL
RLARLGSHSELFS

Download         Length: 282 bp

>T182334 NZ_CP086411:c2733232-2733131 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9658.04 Da        Isoelectric Point: 5.7186

>AT182334 WP_063091831.1 NZ_CP065232:c2449571-2449305 [Thalassospira sp. B30-1]
MSATETYVRARIDSGTKMRATSALDAMGLTVSDAIRLLMLRIADEQRLPFDVKVPNAETREAIEELEAGRGKKSKSVHAL
MAGLHEDD

Download         Length: 267 bp

>AT182334 NZ_CP086411:2733012-2733186 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B9VLJ2

Antitoxin

Source ID Structure
AlphaFold DB A0A1B9VLJ5

References