Detailed information of TA system TA182333

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1701016..1701639
• Replicon: chromosome
• Accession: NZ_CP065232
• Organism: Thalassospira sp. B30-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: IT971_RS08115
• Protein ID: WP_196871159.1
• Coordinates: 1701451..1701639 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IT971_RS08110
• Protein ID: WP_196871158.1
• Coordinates: 1701016..1701402 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT971_RS08065	1696376..1697110	-	735	WP_196871149.1	helix-turn-helix domain-containing protein	-
IT971_RS08070	1697207..1697422	+	216	WP_196871150.1	helix-turn-helix domain-containing protein	-
IT971_RS08075	1697388..1697582	-	195	WP_196871151.1	hypothetical protein	-
IT971_RS08080	1697665..1698048	+	384	WP_196871152.1	hypothetical protein	-
IT971_RS08085	1698045..1698257	+	213	WP_196871153.1	hypothetical protein	-
IT971_RS08090	1698257..1698745	+	489	WP_196871154.1	hypothetical protein	-
IT971_RS08095	1698742..1699116	+	375	WP_196871155.1	hypothetical protein	-
IT971_RS08100	1699113..1700270	+	1158	WP_196871156.1	hypothetical protein	-
IT971_RS08105	1700270..1700947	+	678	WP_196871157.1	hypothetical protein	-
IT971_RS08110	1701016..1701402	-	387	WP_196871158.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IT971_RS08115	1701451..1701639	-	189	WP_196871159.1	type II toxin-antitoxin system HicA family toxin	Toxin
IT971_RS08120	1702027..1702515	+	489	WP_196871160.1	hypothetical protein	-
IT971_RS08125	1702512..1702727	+	216	WP_196871161.1	hypothetical protein	-
IT971_RS08130	1702729..1704228	+	1500	WP_196871162.1	hypothetical protein	-
IT971_RS08135	1704521..1705150	+	630	WP_196871163.1	hypothetical protein	-
IT971_RS08140	1705516..1705767	-	252	WP_196871164.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1691645..1737736	46091

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (8-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7003.19 Da
• Isoelectric Point: 11.2826

>T182333 WP_196871159.1 NZ_CP065232:c1701639-1701451 [Thalassospira sp. B30-1]
MDSKSIIKALEADGWFLVNVKGSHHQFKHPSKPGRTTVLHPKKDIRIGTLRSIEKQSGVKLR

Nucleotide

• Length: 189 bp

>T182333 NZ_CP086411:652652-652768 [Enterococcus faecalis]
ATGTTGTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTAGTTTTGCAATACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 14177.07 Da
• Isoelectric Point: 4.3702

>AT182333 WP_196871158.1 NZ_CP065232:c1701402-1701016 [Thalassospira sp. B30-1]
MKQTYWGVIFKDDDTDYSIVFPDFPGCVTGGKDMQELLEMANEALTFHIDGMHEDGDDIPVPTAFEALPANPEPECTEIS
RIPVTVAVPGKKRRMNLTLDGNLIDQIEAKHGKRAVSGFLEEAARRAL

Nucleotide

• Length: 387 bp

>AT182333 NZ_CP086411:c652884-652679 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTATTGCAAAACTAATCATCAGTCC