Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1138957..1139627 Replicon chromosome
Accession NZ_CP065232
Organism Thalassospira sp. B30-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IT971_RS05240 Protein ID WP_196871123.1
Coordinates 1139202..1139627 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IT971_RS05235 Protein ID WP_196871122.1
Coordinates 1138957..1139205 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT971_RS05210 1134057..1134284 + 228 WP_196871117.1 AlpA family phage regulatory protein -
IT971_RS05215 1134286..1135137 + 852 WP_196871118.1 helicase RepA family protein -
IT971_RS05220 1135124..1135888 + 765 WP_196871119.1 ABC transporter ATPase -
IT971_RS05225 1136694..1137065 + 372 WP_196871120.1 conjugal transfer transcriptional regulator TraJ -
IT971_RS05230 1137098..1138891 + 1794 WP_196871121.1 relaxase/mobilization nuclease domain-containing protein -
IT971_RS05235 1138957..1139205 + 249 WP_196871122.1 Arc family DNA-binding protein Antitoxin
IT971_RS05240 1139202..1139627 + 426 WP_196871123.1 type II toxin-antitoxin system VapC family toxin Toxin
IT971_RS05245 1139818..1140594 + 777 WP_196871124.1 P-type conjugative transfer protein TrbJ -
IT971_RS05250 1140597..1140770 + 174 WP_172400410.1 hypothetical protein -
IT971_RS05255 1140773..1142212 + 1440 WP_196871125.1 P-type conjugative transfer protein TrbL -
IT971_RS05260 1142217..1142456 + 240 WP_113932712.1 hypothetical protein -
IT971_RS05265 1142521..1142751 + 231 WP_196871126.1 type I toxin-antitoxin system ptaRNA1 family toxin -
IT971_RS05270 1142849..1143103 - 255 WP_196871247.1 hypothetical protein -
IT971_RS05275 1143100..1143321 - 222 WP_196871231.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15139.41 Da        Isoelectric Point: 4.3216

>T182332 WP_196871123.1 NZ_CP065232:1139202-1139627 [Thalassospira sp. B30-1]
MILLDTNVISEQFRAVPDETVIDWLNRQPLETLYLASMTVAELRAGVALMPAGKRRTVLGDSIEHQVLPVFVGRVLPFDM
ACTRAYADVLAAARKAGSGIEAADAVIAAIALESGFSVATRDVSPFLAAGVNVINPWEDQE

Download         Length: 426 bp

>T182332 NZ_CP086411:c349905-349810 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9098.50 Da        Isoelectric Point: 9.3441

>AT182332 WP_196871122.1 NZ_CP065232:1138957-1139205 [Thalassospira sp. B30-1]
MRAVTIRNVPEEVHRAIRVRAAQNGRTLQAEMCEILATAVKPEGRVKLGDLLAGIGRKVKLTDEEMTVFDRDHSPARAAS
FE

Download         Length: 249 bp

>AT182332 NZ_CP086411:349711-349775 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References