182329

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 1535506..1536290 Replicon chromosome
Accession NZ_CP065230
Organism Halomonas sp. A40-4

Toxin (Protein)


Gene name dhiT Uniprot ID A0A1A0FJ85
Locus tag IT895_RS07205 Protein ID WP_066317314.1
Coordinates 1535506..1535775 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID A0A1A0FJ86
Locus tag IT895_RS07210 Protein ID WP_066317313.1
Coordinates 1535769..1536290 (+) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT895_RS07170 1530547..1531563 + 1017 WP_066317325.1 metallophosphoesterase -
IT895_RS07175 1531810..1532658 + 849 WP_199285115.1 rhomboid family intramembrane serine protease -
IT895_RS07180 1532673..1532957 + 285 WP_199285116.1 DUF1315 family protein -
IT895_RS07185 1532986..1533786 + 801 WP_199285431.1 DUF2797 domain-containing protein -
IT895_RS07190 1533793..1534098 - 306 WP_066317317.1 winged helix-turn-helix domain-containing protein -
IT895_RS07195 1534140..1535225 - 1086 WP_199285117.1 PA0069 family radical SAM protein -
IT895_RS07200 1535319..1535439 + 121 Protein_1394 damage-inducible protein DinB -
IT895_RS07205 1535506..1535775 + 270 WP_066317314.1 DUF4160 domain-containing protein Toxin
IT895_RS07210 1535769..1536290 + 522 WP_066317313.1 DUF2442 domain-containing protein Antitoxin
IT895_RS07215 1536510..1538177 - 1668 WP_199285118.1 glucose-6-phosphate isomerase -
IT895_RS07220 1538763..1539593 + 831 WP_199285119.1 transketolase -
IT895_RS07225 1539596..1540534 + 939 WP_199285120.1 transketolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Uncharacterized protein HI1420

(65-166)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10303.88 Da        Isoelectric Point: 6.8324

>T182329 WP_066317314.1 NZ_CP065230:1535506-1535775 [Halomonas sp. A40-4]
MPEIDALLGLSFCMYFFDNKQHKLPHLHVKYGGYELIIAIESGECLEGYLPNKHRKRAENHIAEHREQLMHMWQKAVNGE
NPGKLGDIC

Download         Length: 270 bp

>T182329 NZ_CP086408:c4873820-4873509 [Enterobacter cloacae]
ATGCTATTCATTGAAACGGATATCTTCACAGAAGACGTCAAAACGTTACTGGATGACGACGAATACCATAAGCTTCAGGT
GTTCCTGGCAACACAACCTGATTATGGCGATCTGATCCAGAATACCGGGGGGCTGCGAAAGATTCGTTGGCTTTCAGGAG
GCAGGGGAAAGCGCGGTGGAGTAAGGGTTATTTATTTTCATCGTACCCACGAGTTTGAAATCAGATTGCTGCTCATCTAT
CGCAAAGGGATCAAAGATGACCTGTCCGCGAGAGAAAAAGCCATTCTGAAAAAGATGATTGAGAGGTGGTAA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 18856.32 Da        Isoelectric Point: 8.4641

>AT182329 WP_066317313.1 NZ_CP065230:1535769-1536290 [Halomonas sp. A40-4]
MLKIIDVDLVGSYTLELVFSDGFHGVADLSGYFSKAPFSGIKDFQKFSLTAAGSLNWGGNELSASTLRAVTKGVQKTAAT
HFNVQEMEDVIKQASWDSMQEGRPDILQAAIRSYVEQFGHSQVIAKAGIKSRTSAYRSLKPQTTPNFATLVQLGHAVIEL
AKENVSERSTAQR

Download         Length: 522 bp

>AT182329 NZ_CP086408:c4873508-4873218 [Enterobacter cloacae]
ATGGATAAGGCACTCTTTGAGCGATTAACACAAAGCATAGCTCAGATGGATGACATTATCGGGGGGAAACGCGAGCCGTC
GCGCACCTTTCAAATCGATGCGATGAAAATCAAAGAAATTCGTCAGGCGTCTGGGTTGTCCCAAAGTAAATTCGCGAACT
TAATCTCAGTCAGCGTTGATACGTTGCGTAACTGGGAACAAGGACGACGTTCGCCTACCGGTCCCGCAAAGGCATTGTTG
CGTGCAATTGCGAATGATCCACAGCACGTTATTTCGGCTTTATCAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A0FJ85

Antitoxin

Source ID Structure
AlphaFold DB A0A1A0FJ86

References