Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 972298..972811 Replicon chromosome
Accession NZ_CP065230
Organism Halomonas sp. A40-4

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag IT895_RS04615 Protein ID WP_199284837.1
Coordinates 972298..972561 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag IT895_RS04620 Protein ID WP_199284838.1
Coordinates 972551..972811 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT895_RS04595 968770..969459 + 690 WP_199285409.1 VIT family protein -
IT895_RS04600 969553..970179 + 627 WP_199284834.1 SDR family oxidoreductase -
IT895_RS04605 970205..971188 - 984 WP_199284835.1 aldo/keto reductase -
IT895_RS04610 971251..972192 + 942 WP_199284836.1 LysR family transcriptional regulator -
IT895_RS04615 972298..972561 + 264 WP_199284837.1 BrnT family toxin Toxin
IT895_RS04620 972551..972811 + 261 WP_199284838.1 CopG family transcriptional regulator Antitoxin
IT895_RS04625 972823..973728 - 906 WP_199284839.1 LysR family transcriptional regulator -
IT895_RS04630 973833..975062 + 1230 WP_199284840.1 tryptophan synthase subunit beta -
IT895_RS04635 975107..975925 + 819 WP_199285410.1 tryptophan synthase subunit alpha -
IT895_RS04640 976033..976257 + 225 WP_199284841.1 addiction module protein -
IT895_RS04645 976254..976544 + 291 WP_199284842.1 type II toxin-antitoxin system RelE/ParE family toxin -
IT895_RS04650 976609..977214 - 606 WP_199284843.1 LysE family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10298.59 Da        Isoelectric Point: 4.5642

>T182328 WP_199284837.1 NZ_CP065230:972298-972561 [Halomonas sp. A40-4]
MSDFEYDDDKSVANLIKHGIDFLDAQALWNDPDLLEIQAKSDDEPRFLMIGLIDDKHWSAVITYRNEKIRLISVRRSRKR
EVELYES

Download         Length: 264 bp

>T182328 NZ_CP086408:c4069630-4069139 [Enterobacter cloacae]
ATGATCTCTGCCCCAGAGCCCCTTCACGCCGGTCATATTCTTACTCCATTTTGCTGTGGTGTGGATTCGATGGATAACTG
GCTGAAGCAGCGGGCGATGAAAAATCAGGTCAGTGGTGCATCCCGTACCTTTGTCTGTTGTGGCAACGATTCTAACGTTC
TGGCTTATTACTCGCTGGCATCCAGTGCGGTCATGACGAATACCGCACCCGGTCGCTTTCGTCGCAATATGCCCGATCCC
ATCCCGGTTGTTGTGCTGGGACGCCTGGCGGTAGATCAGTCTCTGCATGGGCAGGGCGTTGGTCGGGCACTGGTACGCGA
CGCTGGGCTGCGGGTGATCCAGGTGGCGGAGACCATCGGCATTCGCGGAATGCTGGTTCATGCGCTGTCGGATGAAGCGC
GGGAATTTTATCTGCGGGTGGGGTTTGAGCCATCGCCAATGGATCCGATGATATTGATGGTGACGTTGGGGGATTTGATG
GCGAGTATTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9857.01 Da        Isoelectric Point: 4.8187

>AT182328 WP_199284838.1 NZ_CP065230:972551-972811 [Halomonas sp. A40-4]
MKANDFDQKFDQGSEDIVDDLDLSTAHRVNQDPKRINVDFPAWVVESLDREAARIGVTRQSIIKVWLVERLKAEASQKLP
DNTQPH

Download         Length: 261 bp

>AT182328 NZ_CP086408:c4069920-4069627 [Enterobacter cloacae]
ATGCCAGCTGCAAACACTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAGGCCTGCCGAGCGAGATCTTATCGA
TCGGGCGGCGAAAGCGAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCAGCCCGCGCTGCTGCGGAAGAGGCACTGA
TCGAACAACGCATCATAATGGCCGATCCAGAGGCTTATCAGGAATTTCTGGCTCGTCTGGATCAGGCTCCAGCACCTAAT
GCCACACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAGCGGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References