Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 14664..15226 Replicon plasmid p-ED653
Accession NZ_CP065208
Organism Vibrio cyclitrophicus strain ED653

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag ITG08_RS22830 Protein ID WP_102277806.1
Coordinates 14664..14966 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag ITG08_RS22835 Protein ID WP_102277808.1
Coordinates 14966..15226 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG08_RS22810 (ITG08_22760) 9840..10562 - 723 WP_029203609.1 hypothetical protein -
ITG08_RS22815 (ITG08_22765) 11976..13001 + 1026 WP_102277803.1 DNA mismatch repair protein -
ITG08_RS22820 (ITG08_22770) 12998..13912 + 915 WP_102277804.1 AAA family ATPase -
ITG08_RS22825 (ITG08_22775) 14049..14660 + 612 WP_102277805.1 recombinase family protein -
ITG08_RS22830 (ITG08_22780) 14664..14966 - 303 WP_102277806.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ITG08_RS22835 (ITG08_22785) 14966..15226 - 261 WP_102277808.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ITG08_RS22840 (ITG08_22790) 15444..15992 + 549 WP_102277784.1 recombinase family protein -
ITG08_RS22845 (ITG08_22795) 16045..17421 + 1377 WP_102277785.1 hypothetical protein -
ITG08_RS22850 (ITG08_22800) 17423..18118 + 696 WP_102277786.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..30774 30774


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11695.45 Da        Isoelectric Point: 9.6605

>T182316 WP_102277806.1 NZ_CP065208:c14966-14664 [Vibrio cyclitrophicus]
MTHYKLSSAAQSDLIEIRRYTLERWGQTQWTTYFSELKQSMELLANNQLLGIGVSELGQNYFRFPLKHHVIYYIQKQEHI
VIAAVLGKHMSPAKHFSQLS

Download         Length: 303 bp

>T182316 NZ_CP086406:c25904-25419 [Enterobacter roggenkampii]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9616.96 Da        Isoelectric Point: 4.1963

>AT182316 WP_102277808.1 NZ_CP065208:c15226-14966 [Vibrio cyclitrophicus]
MQSLTANTAKTKFGDLLMKVQREPVQINKNGSPVAVMMSCEEYEQLEALKLMVVKSRFEQAEADVLSDNLVDGDDFMNAL
DQGKFD

Download         Length: 261 bp

>AT182316 NZ_CP086406:c26158-25892 [Enterobacter roggenkampii]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References