Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4759188..4759816 Replicon chromosome
Accession NZ_CP065202
Organism Pseudomonas fragi strain A13BB

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I5R27_RS21725 Protein ID WP_095039773.1
Coordinates 4759188..4759586 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I5R27_RS21730 Protein ID WP_169844997.1
Coordinates 4759586..4759816 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5R27_RS21705 4755615..4756523 - 909 WP_016782506.1 LysR family transcriptional regulator -
I5R27_RS21710 4756631..4757863 + 1233 WP_196883251.1 D-amino acid dehydrogenase -
I5R27_RS21715 4757894..4758244 + 351 WP_016782508.1 RidA family protein -
I5R27_RS21720 4758267..4759169 + 903 WP_016782509.1 transporter substrate-binding domain-containing protein -
I5R27_RS21725 4759188..4759586 - 399 WP_095039773.1 tRNA(fMet)-specific endonuclease VapC Toxin
I5R27_RS21730 4759586..4759816 - 231 WP_169844997.1 antitoxin Antitoxin
I5R27_RS21735 4759962..4760297 - 336 Protein_4244 DUF3077 domain-containing protein -
I5R27_RS21740 4760757..4761476 - 720 WP_016782510.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
I5R27_RS21745 4761613..4763019 - 1407 WP_086795681.1 adenosylmethionine--8-amino-7-oxononanoate transaminase -
I5R27_RS21750 4763292..4763843 + 552 WP_016782512.1 cytochrome b -
I5R27_RS21755 4763876..4764451 + 576 WP_016782513.1 YceI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15071.41 Da        Isoelectric Point: 7.2429

>T182314 WP_095039773.1 NZ_CP065202:c4759586-4759188 [Pseudomonas fragi]
MLKFMLDTNICIFVIKNRPEYVRSYFRVHEGQLCISTVTLMELIYGAEKSSNPEQNLRVIEGFAARLEVLAYDQFAAIHT
GQLRAELARTGKPIGPYDQMIAGHARSQGLILVTNNTREFERVPGLRIEDWV

Download         Length: 399 bp

>T182314 NZ_CP086405:c3967773-3967363 [Enterobacter roggenkampii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGCTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAAATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAATGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8604.65 Da        Isoelectric Point: 4.3950

>AT182314 WP_169844997.1 NZ_CP065202:c4759816-4759586 [Pseudomonas fragi]
MEQGAIFLSNRSQAVRLPKAAALPDDVKRVDIVSIGRARIITPVGECWDSWFEGEGVTPDFMTDRDQPPEQRRDDF

Download         Length: 231 bp

>AT182314 NZ_CP086405:c3968020-3967754 [Enterobacter roggenkampii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGACGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References