Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3752861..3754099 Replicon chromosome
Accession NZ_CP065202
Organism Pseudomonas fragi strain A13BB

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I5R27_RS17020 Protein ID WP_095004262.1
Coordinates 3753524..3754099 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I5R27_RS17015 Protein ID WP_196882745.1
Coordinates 3752861..3753418 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5R27_RS17000 3749016..3750035 + 1020 WP_196882733.1 HindIII family type II restriction endonuclease -
I5R27_RS17005 3750025..3750255 + 231 WP_196882735.1 helix-turn-helix domain-containing protein -
I5R27_RS17010 3750252..3751187 - 936 WP_196882737.1 site-specific DNA-methyltransferase -
I5R27_RS17015 3752861..3753418 + 558 WP_196882745.1 helix-turn-helix domain-containing protein Antitoxin
I5R27_RS17020 3753524..3754099 + 576 WP_095004262.1 HD domain-containing protein Toxin
I5R27_RS17025 3754440..3754814 - 375 WP_196882747.1 type II toxin-antitoxin system VapC family toxin -
I5R27_RS17030 3754811..3755038 - 228 WP_196882749.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
I5R27_RS17040 3755823..3756512 + 690 WP_016779980.1 crotonase/enoyl-CoA hydratase family protein -
I5R27_RS17045 3756736..3757518 + 783 WP_196882751.1 1-acylglycerol-3-phosphate O-acyltransferase -
I5R27_RS17050 3757602..3758573 + 972 WP_016779978.1 magnesium and cobalt transport protein CorA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(9-183)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.66 Da        Isoelectric Point: 4.6835

>T182313 WP_095004262.1 NZ_CP065202:3753524-3754099 [Pseudomonas fragi]
MDIEKIKGRLEFLREAEKLKDVLRSAHTSSGRTESTAEHSWRLCLMAVVFGDYLTGLDRLKMLKMCVIHDLGEAISGDIP
AVNKDSFPNKSEQERNDLILLTNTLDESLKAEILALWDDYENALSPEAVAVKALDKLETMLQHNQGKNPPDFDYEFNLAY
GKKYTDAAPLFEALRNIIDEETKANMLLNPK

Download         Length: 576 bp

>T182313 NZ_CP086405:c3575187-3574900 [Enterobacter roggenkampii]
GTGCCCGAGCTTGAATGGTCCCAACTGGCACGAGCGGATTTACTGGCAATTGTCGATTATATCTCAGACGACAATCCTGA
CGCCGCTCAATGGCTGAAAGATGATATCGAAGCCAAGGCAGCTAAGCTTCCGGAACATCCGAAGCTCTATCGAGGGGGGC
GGATAGAGGGCACGCGCGAAATGGTCGTAAGGGCAAACTACATTGTCGTATACACGGAGGACTCTTTTGCCGTGCGTATA
CTGCGTGTGCTGCACGCAGCGCAACAGTGGCCGCCAACTCAGGAGTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20538.72 Da        Isoelectric Point: 7.8569

>AT182313 WP_196882745.1 NZ_CP065202:3752861-3753418 [Pseudomonas fragi]
MPDMLLKPSLPGVMLRRWRLLHQVKQSHAAELFSVTQSTISRWESGVLDLDSLAHEKLEKLLTARLTTAADQALGRMVRE
SSRPVHLICDLTHRLLACSSSRAAQFASPVSELLGSSLWRFATPTIISMEADLDRLGWREAFAPPALEFLTGDNHSSIVP
ISQGLCRWTRIPLSDGATTRLVESL

Download         Length: 558 bp

>AT182313 NZ_CP086405:c3575473-3575174 [Enterobacter roggenkampii]
ATGGCTGCTCAAACATCCATGCTGCACATCCGTGTAGACGACAAGCTGAAGGCTGATGCGACCGAAAAGCTCGCTAACGT
TGGTCTATCAGTCTCGGATGCCGTGCGAATTTTCCTGACTCGCGTCACCAAAGAAGGCGGTTTGCCTGTGGGACTGACAA
CTGACCCGGAAGCCCATGACAAGTGGTTCCGCGCCAAGGTGCATGAGGCTTTGTCGGACAGCCAGCCGGATGTACCACAT
CAACAGGTAATGGACGAGGCGCAAGATCTTATCGACAGGAAGCGCCGTGCCCGAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References