Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 416865..417492 Replicon chromosome
Accession NZ_CP065202
Organism Pseudomonas fragi strain A13BB

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag I5R27_RS01950 Protein ID WP_086799343.1
Coordinates 416865..417044 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I5R27_RS01955 Protein ID WP_086799341.1
Coordinates 417085..417492 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5R27_RS01935 412870..413817 - 948 WP_086799350.1 DNA-binding transcriptional regulator DsdC -
I5R27_RS01940 413901..415247 - 1347 WP_196883466.1 D-serine ammonia-lyase -
I5R27_RS01945 415291..416631 - 1341 WP_086799346.1 gluconate:H+ symporter -
I5R27_RS01950 416865..417044 + 180 WP_086799343.1 type II toxin-antitoxin system HicA family toxin Toxin
I5R27_RS01955 417085..417492 + 408 WP_086799341.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I5R27_RS01960 417589..420027 - 2439 WP_086799338.1 TonB-dependent siderophore receptor -
I5R27_RS01965 420140..421087 - 948 WP_196883468.1 FecR domain-containing protein -
I5R27_RS01970 421087..421587 - 501 WP_086799334.1 sigma-70 family RNA polymerase sigma factor -
I5R27_RS01975 421827..422024 + 198 WP_081481088.1 type II toxin-antitoxin system HicA family toxin -
I5R27_RS01980 422021..422431 + 411 WP_016783077.1 type II toxin-antitoxin system HicB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6718.88 Da        Isoelectric Point: 10.9432

>T182310 WP_086799343.1 NZ_CP065202:416865-417044 [Pseudomonas fragi]
MHSRQLITALEADGWYLVRSKGSHHHFKHPTKPGLVTIPHPKKDLLTKTINSILKQAQL

Download         Length: 180 bp

>T182310 NZ_CP086405:c1082897-1082679 [Enterobacter roggenkampii]
ATGTCTGATAAACCACTCACTAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACCCTCGAACGCGT
GATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCCGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAGC
TGACCATGAATAAGTTGTATGACAAAATCCCTACTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14715.79 Da        Isoelectric Point: 4.7465

>AT182310 WP_086799341.1 NZ_CP065202:417085-417492 [Pseudomonas fragi]
MLYPIAIRPGDEQHAWGVEVPDIPGCFSAGENLDDAMAMAREAIEGHLEILAEDCSRIPVATPVSAHVANPEYGGCIWAL
VDIDITRYLGKAEKLNITLPGNLLNRIDEYVKHHPEQKSRSGFLASAALKVLQQA

Download         Length: 408 bp

>AT182310 NZ_CP086405:c1083299-1082925 [Enterobacter roggenkampii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAACCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGTTACGGCATTAACGCCCAGGATTTGCAAAAATGGCGTAAATCGGGAAACCGGCT
ATTCCGCTGTTTTGTCAACGTGAGCAGAGCTAACCCGGTTAGCCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References