Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 873694..874171 Replicon chromosome
Accession NZ_CP065199
Organism Staphylococcus aureus strain DG36

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag I3K83_RS04165 Protein ID WP_000052076.1
Coordinates 873694..873882 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag I3K83_RS04170 Protein ID WP_001059690.1
Coordinates 873911..874171 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3K83_RS04135 869729..870205 + 477 WP_000824477.1 hypothetical protein -
I3K83_RS04140 870546..871232 + 687 WP_001641381.1 thermonuclease family protein -
I3K83_RS04145 871589..871789 + 201 WP_001059082.1 cold-shock protein -
I3K83_RS04150 872285..872503 - 219 WP_000005887.1 hypothetical protein -
I3K83_RS04155 872565..872849 - 285 WP_031590186.1 hypothetical protein -
I3K83_RS04160 872937..873506 - 570 WP_001106652.1 hypothetical protein -
I3K83_RS04165 873694..873882 - 189 WP_000052076.1 hypothetical protein Toxin
I3K83_RS04170 873911..874171 - 261 WP_001059690.1 hypothetical protein Antitoxin
I3K83_RS04175 874512..874715 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
I3K83_RS04180 874712..874948 - 237 WP_000368687.1 hypothetical protein -
I3K83_RS04185 875173..875754 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
I3K83_RS04190 875827..876444 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
I3K83_RS04195 876600..877094 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
I3K83_RS04200 877493..877915 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
I3K83_RS04205 878063..878779 + 717 WP_031589686.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T182298 WP_000052076.1 NZ_CP065199:c873882-873694 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T182298 NZ_CP086391:3195784-3196002 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT182298 WP_001059690.1 NZ_CP065199:c874171-873911 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT182298 NZ_CP086391:3195384-3195758 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References