Detailed information of TA system TA182287

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1617724..1618500
• Replicon: chromosome
• Accession: NZ_CP065194
• Organism: Staphylococcus aureus strain GDC6P096P

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: I3K80_RS07920
• Protein ID: WP_000031108.1
• Coordinates: 1617724..1617876 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: I3K80_RS07925
• Protein ID: WP_074371037.1
• Coordinates: 1617901..1618500 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I3K80_RS07905	1613929..1614750	+	822	WP_000669380.1	RluA family pseudouridine synthase	-
I3K80_RS07910	1615205..1616590	-	1386	WP_000116238.1	class II fumarate hydratase	-
I3K80_RS07915	1616786..1617181	-	396	WP_000901018.1	hypothetical protein	-
I3K80_RS07920	1617724..1617876	-	153	WP_000031108.1	hypothetical protein	Toxin
I3K80_RS07925	1617901..1618500	-	600	WP_074371037.1	glucosamine-6-phosphate isomerase	Antitoxin
I3K80_RS07930	1618659..1619129	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
I3K80_RS07935	1619134..1620261	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
I3K80_RS07940	1620412..1621134	-	723	WP_031774878.1	amino acid ABC transporter ATP-binding protein	-
I3K80_RS07945	1621127..1622584	-	1458	WP_000649908.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T182287 WP_000031108.1 NZ_CP065194:c1617876-1617724 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T182287 NZ_CP086391:672170-672505 [Escherichia coli]
ATGGTAAGCCGAAACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22355.53 Da
• Isoelectric Point: 5.1445

>AT182287 WP_074371037.1 NZ_CP065194:c1618500-1617901 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLILQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT182287 NZ_CP086391:671922-672170 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: X5E2E6