182286

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1404598..1405706 Replicon chromosome
Accession NZ_CP065194
Organism Staphylococcus aureus strain GDC6P096P

Toxin (Protein)


Gene name MNTss Uniprot ID A0A0M4MHJ8
Locus tag I3K80_RS06900 Protein ID WP_002303392.1
Coordinates 1404598..1405467 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID B9DSK1
Locus tag I3K80_RS06905 Protein ID WP_002303393.1
Coordinates 1405482..1405706 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3K80_RS06855 1399693..1400001 - 309 WP_000457386.1 50S ribosomal protein L21 -
I3K80_RS06860 1400488..1401018 - 531 WP_001259929.1 rod shape-determining protein MreD -
I3K80_RS06865 1401018..1401860 - 843 WP_000911033.1 rod shape-determining protein MreC -
I3K80_RS06870 1402058..1402177 - 120 WP_000840603.1 hypothetical protein -
I3K80_RS06875 1402251..1402724 - 474 WP_001236734.1 DUF4930 family protein -
I3K80_RS06880 1402884..1403081 + 198 WP_000025835.1 hypothetical protein -
I3K80_RS06885 1403198..1403482 - 285 WP_000171859.1 hypothetical protein -
I3K80_RS06890 1403550..1403696 - 147 Protein_1350 hypothetical protein -
I3K80_RS06895 1403931..1404566 - 636 WP_074347692.1 methyltransferase domain-containing protein -
I3K80_RS06900 1404598..1405467 - 870 WP_002303392.1 nucleotidyltransferase domain-containing protein Toxin
I3K80_RS06905 1405482..1405706 - 225 WP_002303393.1 helix-turn-helix transcriptional regulator Antitoxin
I3K80_RS06910 1405849..1406670 - 822 Protein_1354 recombinase zinc beta ribbon domain-containing protein -
I3K80_RS06915 1407358..1408161 - 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
I3K80_RS06920 1408215..1409699 - 1485 WP_074371031.1 ABC-F type ribosomal protection protein Lsa(E) -
I3K80_RS06925 1410142..1410702 - 561 Protein_1357 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island lnu(B) / lsa(E) - 1403198..1411587 8389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32807.38 Da        Isoelectric Point: 4.7269

>T182286 WP_002303392.1 NZ_CP065194:c1405467-1404598 [Staphylococcus aureus]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

>T182286 NZ_CP086391:534573-534980 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8351.65 Da        Isoelectric Point: 4.5357

>AT182286 WP_002303393.1 NZ_CP065194:c1405706-1405482 [Staphylococcus aureus]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE

Download         Length: 225 bp

>AT182286 NZ_CP086391:534326-534592 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4MHJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A1M5SHM7

References