Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3443746..3444386 Replicon chromosome
Accession NZ_CP065178
Organism Pectobacterium quasiaquaticum strain A398-S21-F17

Toxin (Protein)


Gene name vagD Uniprot ID A0A7V8Q162
Locus tag IG605_RS15845 Protein ID WP_039278477.1
Coordinates 3443746..3444162 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A086EF97
Locus tag IG605_RS15850 Protein ID WP_039278475.1
Coordinates 3444159..3444386 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG605_RS15825 (IG605_015770) 3439334..3440317 - 984 WP_193398322.1 quinone oxidoreductase -
IG605_RS15830 (IG605_015775) 3440445..3441851 + 1407 WP_039490832.1 replicative DNA helicase -
IG605_RS15835 (IG605_015780) 3441893..3442975 + 1083 WP_193398321.1 alanine racemase -
IG605_RS15840 (IG605_015785) 3442968..3443606 + 639 WP_193401588.1 hypothetical protein -
IG605_RS15845 (IG605_015790) 3443746..3444162 - 417 WP_039278477.1 type II toxin-antitoxin system VapC family toxin Toxin
IG605_RS15850 (IG605_015795) 3444159..3444386 - 228 WP_039278475.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IG605_RS15855 (IG605_015800) 3446023..3446502 + 480 WP_102117289.1 Lrp/AsnC family transcriptional regulator -
IG605_RS15860 (IG605_015805) 3446752..3447366 + 615 WP_193407245.1 YitT family protein -
IG605_RS15865 (IG605_015810) 3447431..3448624 + 1194 WP_193407243.1 amino acid aminotransferase -
IG605_RS15870 (IG605_015815) 3448706..3449203 + 498 WP_193407241.1 M48 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15274.80 Da        Isoelectric Point: 8.2931

>T182278 WP_039278477.1 NZ_CP065178:c3444162-3443746 [Pectobacterium quasiaquaticum]
VSRLFMLDTNICSFIMREHPAEVIEKLQQCTLRRDRIVVSAITYAEMRFGAVGKKASPRHMQLVDAFCRRLDAVLPWDSA
AVDATTKIKIELAAAGTPIGPNDTAIAGHAISAKAILVTNNLREFERVPGLTLEDWVK

Download         Length: 417 bp

>T182278 NZ_CP086384:57711-58043 [Deinococcus radiophilus]
ATCAGACGGGGCGAGATTTACCTGGTGGATCTGAATCCCACGGCCGGACATGAGCAGCGTGGCAAACGTCCAGTCCTGGT
GGTGTCGCCGGATGCCTTCAACGCCCTGACCGGTACGCCCATTGTCCTGCCAGTGACCAGCGGAGGACAGTTCGCACGGA
TGGCCGGGTTTGCGGTGTCCCTGGACGAAGCTGGAACCCAGACCACGGGCATCGTGCGCTGTGATCAGCCCAGGGCACTT
GATTTCAGCGCGCGGGGAGCCCGCCTTCTTGAGATGGTGCCCCGGGATGTGGTGGATGAGGTGCTGGCGCGTCTGGCGGT
ACTGTTCAGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8879.08 Da        Isoelectric Point: 4.8359

>AT182278 WP_039278475.1 NZ_CP065178:c3444386-3444159 [Pectobacterium quasiaquaticum]
MRIVSVFKNGNNRAIRLPRDMDFEGVNELEIVREGDTIMLRPVKPNWHSFLQEDRADADFMTERQDVVEEGRFKL

Download         Length: 228 bp

>AT182278 NZ_CP086384:57406-57699 [Deinococcus radiophilus]
GTGCATAAGACATACCTGAGAAAAGTCGGCGGTTCGGTGATGTTGAGTATTCCCCCTGCATTGCTGGACGTTCTGGAATT
GACTGCAGGCACCGCTGTGGGCCTAAACGTCGAAGGGAGGCAGTTGACGGTTCAGCCAGCCCCAAAACCGCGTTACTCCC
TGGAAGAACTGCTGGCGCAGTGTGATTTAGAAGCGCAGTGTGATTTAGAAGCGCAGTGTGATCCAGCAGGAGCGCAGGAC
GCAGAAGAACAGCATTGGCTGAGTGACGCGCCGGTGGGGCGTGAGGTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8Q162

Antitoxin

Source ID Structure
AlphaFold DB A0A086EF97

References