Detailed information of TA system TA182277

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 3279506..3280032
• Replicon: chromosome
• Accession: NZ_CP065178
• Organism: Pectobacterium quasiaquaticum strain A398-S21-F17

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: IG605_RS15085
• Protein ID: WP_193407951.1
• Coordinates: 3279727..3280032 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: IG605_RS15080
• Protein ID: WP_039522980.1
• Coordinates: 3279506..3279724 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG605_RS15070 (IG605_015020)	3276593..3277856	+	1264	Protein_2926	tyrosine-type recombinase/integrase	-
IG605_RS15075 (IG605_015025)	3278704..3279447	+	744	WP_193407950.1	MobC family replication-relaxation protein	-
IG605_RS15080 (IG605_015030)	3279506..3279724	+	219	WP_039522980.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
IG605_RS15085 (IG605_015035)	3279727..3280032	+	306	WP_193407951.1	type II toxin-antitoxin system toxin CcdB	Toxin
IG605_RS15090 (IG605_015040)	3280602..3280603	-	2	WP_250116837.1	IS5 family transposase	-
IG605_RS15095 (IG605_015045)	3281404..3283113	+	1710	WP_193407102.1	site-specific DNA-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3277473..3292319	14846

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-100)

Antitoxin

• Post-segregation antitoxin CcdA (2-72)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11802.64 Da
• Isoelectric Point: 4.8616

>T182277 WP_193407951.1 NZ_CP065178:3279727-3280032 [Pectobacterium quasiaquaticum]
MQFIVYQYKRTSHYKIFVDVQSDIVETPKRRMVIPLIESHHLSEKVNKTLFPLIRINGEDYRLMTTELSSVPVEVIGEEI
ADLGDYADEIKDAINLMFWGI

Nucleotide

• Length: 306 bp

>T182277 NZ_CP086382:115889-116308 [Deinococcus radiophilus]
ATGTACCTGCTGGATACCAATGTCATTTCGGAACTGCGCAAGGTGAAGTCAGGACGGGCGAACGAAGGAGTCGTCGCCTG
GTCGCAGACGGTGACGACGGCAGAGCTTTACCTCTCCGTCATCACGGTCCAGGAATTGGAATTAGGTGTCCTGCTTAAGG
AACGCCGTGATCTACAGCAAGGAGCAGTACTTCGAAAATGGTTGGACGGCCAGGTGCTCCCAGCCTTTGCAGGACGCATC
CTACCGATCACCCTGGAGATCGCCCGGCGAACAGCGAATCTGAACGTTCCCCAGCAGCGGGCCTTTTACGACAGTCTGAT
TGCGGCGACGGCCCTGGAGCACGGCTACACCCTAGTGACCAGGAATGAAGCGGACATGCAGGGAACCGGCGTCGAGATCG
TCAATCCCTTTCAGTCCTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8093.06 Da
• Isoelectric Point: 8.6383

>AT182277 WP_039522980.1 NZ_CP065178:3279506-3279724 [Pectobacterium quasiaquaticum]
MKHRVSVTVDKDSYQVLSAAGVNISGLVNDAIGKEARRIKAEAWKKENREGMEEVARFIAQNGSFADENRNW

Nucleotide

• Length: 219 bp

>AT182277 NZ_CP086382:115647-115889 [Deinococcus radiophilus]
ATGACGACTATTAGTGCCCGTGAGTTCAACCAGCAGGTCAGCAAGGTCCGTAAAGCCGCCTCTAAAGAACCGGTCTTCAT
TACCGAACGCGGAGAGCCCAAACATGTCTTGCTGAGTATCGAGGCCTATGAAGCCCTCACCGGCAGTCAGCGGAACATCG
CCGACCTCCTGGCACTGGACGAAGACATCGACTTCGAACTTCCACAGCGCTCCGAGCTCACCCGCGCCGCGGAGCTGGAC
TGA