Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3250711..3251747 Replicon chromosome
Accession NZ_CP065178
Organism Pectobacterium quasiaquaticum strain A398-S21-F17

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag IG605_RS14945 Protein ID WP_193407943.1
Coordinates 3250711..3251286 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag IG605_RS14950 Protein ID WP_193397972.1
Coordinates 3251286..3251747 (-) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG605_RS14925 (IG605_014875) 3248577..3248969 - 393 WP_193400082.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
IG605_RS14930 (IG605_014880) 3248956..3249411 - 456 WP_226373438.1 YgdB family protein -
IG605_RS14935 (IG605_014885) 3249408..3249959 - 552 WP_250116875.1 prepilin peptidase-dependent protein -
IG605_RS14940 (IG605_014890) 3250028..3250531 - 504 WP_193407942.1 prepilin peptidase-dependent protein -
IG605_RS14945 (IG605_014895) 3250711..3251286 - 576 WP_193407943.1 PIN domain-containing protein Toxin
IG605_RS14950 (IG605_014900) 3251286..3251747 - 462 WP_193397972.1 helix-turn-helix domain-containing protein Antitoxin
IG605_RS14955 (IG605_014905) 3252026..3252820 - 795 WP_039312476.1 thymidylate synthase -
IG605_RS14960 (IG605_014910) 3252857..3253723 - 867 WP_193398010.1 prolipoprotein diacylglyceryl transferase -
IG605_RS14965 (IG605_014915) 3253950..3256196 - 2247 WP_193407944.1 phosphoenolpyruvate--protein phosphotransferase -
IG605_RS14970 (IG605_014920) 3256209..3256742 - 534 WP_102118309.1 RNA pyrophosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21491.94 Da        Isoelectric Point: 4.7230

>T182276 WP_193407943.1 NZ_CP065178:c3251286-3250711 [Pectobacterium quasiaquaticum]
MNHSPYPVVLDACVIYPSLLRDLLMHLGLTGLYQPKWTALIQEEWQRNLLLNNADVTMDKLRNIEHLMNKALPDANVTGF
EQLIPALVLPDADDRHVLAAAIRANAEVIVTVNLKDFPATALSEFAVEAMHPDEFIADLFDLNSALVLKAVRTSRTAFRK
PPFDVDEYLDCLLRQGLPMTVKELDAYRALI

Download         Length: 576 bp

>T182276 NZ_CP086382:115222-115557 [Deinococcus radiophilus]
ATGAAACGTGGTGACATCTATCAAGTCGACTTCGAGCCGAGCGTCCAGGGAGAGCCGGCCAGAAGCCGTCCTGCGGTCAT
CTTGACGAACGACTTGGCGAATGAGGCGCTGCCGCATCTGGTCGTTGCTCCCATCACCAGCAACGTCAGCCGGGAGTATC
CGTTTGACGTGATGCTGCCCGTCGGCACCTGCGGACTTCCGGAAACCAGCCGCGTTCAGCTCAACTACGTCCGTGGGCTC
AACCGCAACAAGTTCGGAGCATATCTCGGCAGCCTGACGCGAGCACAGATGAGTGAACTTGACCGCAAGCTCAAATTGCA
TCTTGGCCTGAGCTGA

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 17216.74 Da        Isoelectric Point: 6.2253

>AT182276 WP_193397972.1 NZ_CP065178:c3251747-3251286 [Pectobacterium quasiaquaticum]
MKNTPLNSLSLPAPKEMEAAIRGQRQLATYLSTKLETQEISIQDAHDIAHRIELPTSALTLLMSILGELAAGNAVQIVPV
QAELTTQEAANILNVSRPHMVKLLEEGHLPFHKTGRHRRVLFADLMQYKEQRESESMQAMQELTDRSQELGFY

Download         Length: 462 bp

>AT182276 NZ_CP086382:115647-115889 [Deinococcus radiophilus]
ATGACGACTATTAGTGCCCGTGAGTTCAACCAGCAGGTCAGCAAGGTCCGTAAAGCCGCCTCTAAAGAACCGGTCTTCAT
TACCGAACGCGGAGAGCCCAAACATGTCTTGCTGAGTATCGAGGCCTATGAAGCCCTCACCGGCAGTCAGCGGAACATCG
CCGACCTCCTGGCACTGGACGAAGACATCGACTTCGAACTTCCACAGCGCTCCGAGCTCACCCGCGCCGCGGAGCTGGAC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References