Detailed information of TA system TA182275

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3071012..3071636
• Replicon: chromosome
• Accession: NZ_CP065178
• Organism: Pectobacterium quasiaquaticum strain A398-S21-F17

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: C6DB72
• Locus tag: IG605_RS14125
• Protein ID: WP_005976087.1
• Coordinates: 3071433..3071636 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: IG605_RS14120
• Protein ID: WP_193397543.1
• Coordinates: 3071012..3071380 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG605_RS14105 (IG605_014070)	3066643..3069771	+	3129	WP_193397542.1	efflux RND transporter permease subunit	-
IG605_RS14110 (IG605_014075)	3070004..3070252	+	249	WP_102116757.1	type B 50S ribosomal protein L31	-
IG605_RS14115 (IG605_014080)	3070270..3070413	+	144	WP_072012464.1	type B 50S ribosomal protein L36	-
IG605_RS14120 (IG605_014085)	3071012..3071380	+	369	WP_193397543.1	Hha toxicity modulator TomB	Antitoxin
IG605_RS14125 (IG605_014090)	3071433..3071636	+	204	WP_005976087.1	HHA domain-containing protein	Toxin
IG605_RS14135 (IG605_014100)	3072380..3072700	+	321	WP_010282239.1	MGMT family protein	-
IG605_RS14140 (IG605_014105)	3072720..3073301	-	582	WP_193407713.1	YbaY family lipoprotein	-
IG605_RS14145 (IG605_014110)	3073512..3074375	+	864	WP_193397545.1	acyl-CoA thioesterase II	-
IG605_RS14150 (IG605_014115)	3074527..3075813	-	1287	WP_167469165.1	ammonium transporter AmtB	-
IG605_RS14155 (IG605_014120)	3075853..3076191	-	339	WP_002208627.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-117)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8145.52 Da
• Isoelectric Point: 8.9008

>T182275 WP_005976087.1 NZ_CP065178:3071433-3071636 [Pectobacterium quasiaquaticum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Nucleotide

• Length: 204 bp

>T182275 NZ_CP086380:c1248612-1248244 [Deinococcus radiophilus]
ATGAGGTATGAGCAAAGGGGTGATCTGCACCTTGGCCCGCTGTGGCTGGATGCCCACCTGCCGCCAGCTTTGGCTCCCTG
GCTGCGCGAGACTTTCGGTATAGAGGCTTACAGTGCGGCCTATCTGGGGCTGCGAGATGCCGAAGATGCTGCAATTTTTG
CTCAGGCGCGTGAGGCTGGGGCCGTTATCGTCTCCAAAGACGCCGATTTTCTTGAGCGAGTCGTGCGTCTGGGACCGCCG
CCCAGGCTGATTTATCTGACCTGCGGAAATACCAGCAAGGCGGCCCTGAAAATACTGTTTGAGCGGCAATTTGAGCAGAT
TGCTATCTTGCTGGAAAGTGGTGAAGCGGTGGTGGAGGTAAGCGGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14102.92 Da
• Isoelectric Point: 4.3697

>AT182275 WP_193397543.1 NZ_CP065178:3071012-3071380 [Pectobacterium quasiaquaticum]
MDEYTPKYYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICMPAKT

Nucleotide

• Length: 369 bp

>AT182275 NZ_CP086380:c1248830-1248609 [Deinococcus radiophilus]
ATGAGCCTGTTGGACCGCATAACCGTCAACCCGCAGCAGTGTGGGGGAAGACCGTGCATTCGTGGTATGCGGATTCGCGT
GTCGGACATTCTGGATCTGCTGGGGGCAGGGGTAGAGGTAGAGGAAATCTTGGCCGACCATCCGGATTTGGAACGTGAGG
ACGTTTATGCGGCATTGACCTGGGCCGCCCGCTACGTTGACCACCCCCGTCTGAGCGCATGA

Structures

Toxin

• AlphaFold DB: A0A1D7Z3F0