Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1053346..1053938 Replicon chromosome
Accession NZ_CP065178
Organism Pectobacterium quasiaquaticum strain A398-S21-F17

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IG605_RS04945 Protein ID WP_116167000.1
Coordinates 1053684..1053938 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A086EVC4
Locus tag IG605_RS04940 Protein ID WP_039276161.1
Coordinates 1053346..1053687 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG605_RS04920 (IG605_004905) 1048357..1049484 - 1128 WP_130622824.1 phage major capsid protein, P2 family -
IG605_RS04925 (IG605_004910) 1049534..1050388 - 855 WP_193407850.1 GPO family capsid scaffolding protein -
IG605_RS04930 (IG605_004915) 1050528..1052297 + 1770 WP_193407838.1 terminase ATPase subunit family protein -
IG605_RS04935 (IG605_004920) 1052294..1053313 + 1020 WP_165708436.1 phage portal protein -
IG605_RS04940 (IG605_004925) 1053346..1053687 - 342 WP_039276161.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IG605_RS04945 (IG605_004930) 1053684..1053938 - 255 WP_116167000.1 type II toxin-antitoxin system HicA family toxin Toxin
IG605_RS04950 (IG605_004935) 1054031..1054693 - 663 WP_226373405.1 ORF6N domain-containing protein -
IG605_RS04955 (IG605_004940) 1054817..1055158 + 342 WP_226373404.1 Arc family DNA-binding protein -
IG605_RS04960 (IG605_004950) 1055872..1056210 - 339 WP_193407836.1 hypothetical protein -
IG605_RS04965 (IG605_004955) 1056210..1056611 - 402 WP_116226549.1 hypothetical protein -
IG605_RS04970 (IG605_004960) 1056614..1058863 - 2250 WP_193407835.1 replication endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1032009..1064838 32829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9554.01 Da        Isoelectric Point: 11.2749

>T182270 WP_116167000.1 NZ_CP065178:c1053938-1053684 [Pectobacterium quasiaquaticum]
MNKRHQKTLSDIFSRPVSGSIKWNDIESLFIALGAEVHEREGSRVAVLLKGEKRIFHRPHPRPTTDKGAVNSIRVWLDSL
GIRP

Download         Length: 255 bp

>T182270 NZ_CP086372:c1491818-1491666 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12347.83 Da        Isoelectric Point: 4.3521

>AT182270 WP_039276161.1 NZ_CP065178:c1053687-1053346 [Pectobacterium quasiaquaticum]
MINTLQIDGHTAVIAFDPEIEMFRGEFVGLNGGADFYAYSVEELKKEGATSLAVFLDECRNDGIEPYKSYSGKVTTRLTP
ERHAALAVTAQANGVSINELLNEGVDLVIERHS

Download         Length: 342 bp

>AT182270 NZ_CP086372:c1491602-1491468 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A086EVC4

References