Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 170987..171604 Replicon chromosome
Accession NZ_CP065178
Organism Pectobacterium quasiaquaticum strain A398-S21-F17

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IG605_RS00765 Protein ID WP_193397751.1
Coordinates 171425..171604 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IG605_RS00760 Protein ID WP_193397752.1
Coordinates 170987..171397 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG605_RS00745 (IG605_000735) 166950..167993 - 1044 WP_193397754.1 DNA-binding transcriptional regulator CytR -
IG605_RS00750 (IG605_000740) 168220..170418 - 2199 WP_193407369.1 primosomal protein N' -
IG605_RS00755 (IG605_000745) 170689..170904 + 216 WP_010281510.1 50S ribosomal protein L31 -
IG605_RS00760 (IG605_000750) 170987..171397 - 411 WP_193397752.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IG605_RS00765 (IG605_000755) 171425..171604 - 180 WP_193397751.1 type II toxin-antitoxin system HicA family toxin Toxin
IG605_RS00770 (IG605_000760) 171688..171801 - 114 Protein_153 iron ABC transporter permease -
IG605_RS00775 (IG605_000765) 172120..172437 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
IG605_RS00780 (IG605_000770) 172625..173785 + 1161 WP_193407370.1 cystathionine gamma-synthase -
IG605_RS00785 (IG605_000775) 173788..176223 + 2436 WP_193407371.1 bifunctional aspartate kinase/homoserine dehydrogenase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6603.76 Da        Isoelectric Point: 10.7838

>T182265 WP_193397751.1 NZ_CP065178:c171604-171425 [Pectobacterium quasiaquaticum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKLGLVTIPHPKKDLPIGTVKNIRKQAGI

Download         Length: 180 bp

>T182265 NZ_CP086370:4295023-4295277 [Massilia sp. HC52]
ATGAAAGCAAAACACCAAAGGACATTGCAGCTGATCTTTTCCAGGCCTACACCGGCCGGTGTCAAGTGGCTGGATGCTGT
TGCATTACTTGAGGCACGCGGGGCAGATATTTCCGAGGCCGAAGGCTCACGTGTAGCCGTGTGTCTTTTTGGGCAGGTGA
AAGTACTGCATCGGCCGCATCCTTCCCCGGACATCGACAAAGGTGCTGTTGCATCCATCCGGAAGTGGCTTGAAGAAAAC
GGAGTGAAACCATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14521.40 Da        Isoelectric Point: 4.4118

>AT182265 WP_193397752.1 NZ_CP065178:c171397-170987 [Pectobacterium quasiaquaticum]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQWAKSAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALARISSSR

Download         Length: 411 bp

>AT182265 NZ_CP086370:4295274-4295648 [Massilia sp. HC52]
ATGAATAACATTATGAAAATCGATGGCCAGCAGGCTGTCATTGCATACGATCCCGAGATTGAACTCTTTAGGGGCGAATT
TATCGGACTGAATGGAGGCGCAGACTTTTACGCGCCAGACGTAGCGGGACTGCAGCGCGAGGGTTCTATTTCACTCGCCG
TATTCCTGCGGACATGCAAAGAACGGGGCATAGAACCGTTCAAGAGCTTTTCAGGCAAATTTGTTCTTCGTGTAGACCCG
GCTGTCCACGAAGCTGCAGCACTGGCCGCTGCCGCGGACGGCAAGAGCTTGAATCAGTGGGCTTCGGACGTCCTCAAAAT
ATCGCTGGAGGCAGCTGATAATTCTTATGCTAGCCCACGGGCTAAACTCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References