Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3606090..3606730 Replicon chromosome
Accession NZ_CP065177
Organism Pectobacterium quasiaquaticum strain A477-S1-J17

Toxin (Protein)


Gene name vagD Uniprot ID A0A7V8Q162
Locus tag IG609_RS16530 Protein ID WP_039278477.1
Coordinates 3606090..3606506 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A086EF97
Locus tag IG609_RS16535 Protein ID WP_039278475.1
Coordinates 3606503..3606730 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG609_RS16505 (IG609_016490) 3601471..3601635 - 165 WP_193398323.1 hypothetical protein -
IG609_RS16510 (IG609_016495) 3601678..3602661 - 984 WP_193398322.1 quinone oxidoreductase -
IG609_RS16515 (IG609_016500) 3602789..3604195 + 1407 WP_039490832.1 replicative DNA helicase -
IG609_RS16520 (IG609_016505) 3604237..3605319 + 1083 WP_193398321.1 alanine racemase -
IG609_RS16525 (IG609_016510) 3605312..3605950 + 639 WP_193398320.1 hypothetical protein -
IG609_RS16530 (IG609_016515) 3606090..3606506 - 417 WP_039278477.1 type II toxin-antitoxin system VapC family toxin Toxin
IG609_RS16535 (IG609_016520) 3606503..3606730 - 228 WP_039278475.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IG609_RS16540 (IG609_016525) 3607344..3607823 + 480 WP_193398319.1 Lrp/AsnC family transcriptional regulator -
IG609_RS16545 (IG609_016530) 3608074..3608688 + 615 WP_010279239.1 YitT family protein -
IG609_RS16550 (IG609_016535) 3608752..3609945 + 1194 WP_193398318.1 amino acid aminotransferase -
IG609_RS16555 (IG609_016540) 3610029..3610526 + 498 WP_193398317.1 M48 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15274.80 Da        Isoelectric Point: 8.2931

>T182259 WP_039278477.1 NZ_CP065177:c3606506-3606090 [Pectobacterium quasiaquaticum]
VSRLFMLDTNICSFIMREHPAEVIEKLQQCTLRRDRIVVSAITYAEMRFGAVGKKASPRHMQLVDAFCRRLDAVLPWDSA
AVDATTKIKIELAAAGTPIGPNDTAIAGHAISAKAILVTNNLREFERVPGLTLEDWVK

Download         Length: 417 bp

>T182259 NZ_CP086369:4253003-4253281 [Pectobacterium versatile]
ATGAAAAAGCAAAGGGAAATTGCATATTCTGGTCAATTCCAACGTGATGTGAAAAAAGCTCAACGGCGACATAAAAACAT
GAACAAGCTTAAAACGCTTATGCAGCTTTTGCTTGAAGACAAACGACCGTTGCCACAGGAATATCAGGATCACCCCCTCC
AGGGAAACTATAAGGGCTACAGAGATGCGCATATCGAGCCGGATTGGCTTCTTATTTACAAGCTGACCGATGACGTTTTG
CGTTTTGAACGTACAGGGACGCACGCTGACCTTTTCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8879.08 Da        Isoelectric Point: 4.8359

>AT182259 WP_039278475.1 NZ_CP065177:c3606730-3606503 [Pectobacterium quasiaquaticum]
MRIVSVFKNGNNRAIRLPRDMDFEGVNELEIVREGDTIMLRPVKPNWHSFLQEDRADADFMTERQDVVEEGRFKL

Download         Length: 228 bp

>AT182259 NZ_CP086369:4252739-4252999 [Pectobacterium versatile]
ATGGCAGCGAATGCATTTGTACGTGCCCGTATTGATGAGAATCTTAAAAATGAAGCAGCGGAAGTGTTGGCTAGCATGGG
GTTGACGGTATCGGATCTGGTGCGCATAACGTTAACGAAAGTGGCTAAAGAAAAAGCACTTCCATTTGATATGCATGTCC
CTAATAAGCTTACCGCACAAACGATGGCTGACAGCGAGAAAGGTGTTGATGTCTATACAGCAAAAGACGCCGCCGATCTG
TTTGATAAATTAGGGATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8Q162

Antitoxin

Source ID Structure
AlphaFold DB A0A086EF97

References