Detailed information of TA system TA182249

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 1251105..1251768
• Replicon: chromosome
• Accession: NZ_CP065177
• Organism: Pectobacterium quasiaquaticum strain A477-S1-J17

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: IG609_RS05745
• Protein ID: WP_193398732.1
• Coordinates: 1251424..1251768 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: IG609_RS05740
• Protein ID: WP_014916192.1
• Coordinates: 1251105..1251422 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG609_RS05705 (IG609_005715)	1246802..1247680	-	879	WP_193398735.1	aldo/keto reductase family oxidoreductase	-
IG609_RS05710 (IG609_005720)	1247710..1248633	-	924	WP_193398734.1	NADP-dependent oxidoreductase	-
IG609_RS05715 (IG609_005725)	1248752..1249354	+	603	WP_193398779.1	TetR/AcrR family transcriptional regulator	-
IG609_RS05720	1249446..1249645	-	200	Protein_1091	DNA-binding protein	-
IG609_RS05725 (IG609_005730)	1249790..1250059	+	270	WP_193398733.1	DUF1778 domain-containing protein	-
IG609_RS05730 (IG609_005735)	1250063..1250554	+	492	WP_039498513.1	GNAT family N-acetyltransferase	-
IG609_RS05735 (IG609_005740)	1250803..1251018	+	216	WP_010279992.1	helix-turn-helix transcriptional regulator	-
IG609_RS05740 (IG609_005745)	1251105..1251422	-	318	WP_014916192.1	helix-turn-helix transcriptional regulator	Antitoxin
IG609_RS05745 (IG609_005750)	1251424..1251768	-	345	WP_193398732.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IG609_RS05750 (IG609_005755)	1252013..1253038	-	1026	WP_193398778.1	IS630 family transposase	-
IG609_RS05755 (IG609_005760)	1253170..1255215	-	2046	WP_226374099.1	discoidin domain-containing protein	-
IG609_RS05760 (IG609_005765)	1255415..1256548	-	1134	WP_193398731.1	linear amide C-N hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1252013..1253038	1025

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-86)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12371.12 Da
• Isoelectric Point: 9.7825

>T182249 WP_193398732.1 NZ_CP065177:c1251768-1251424 [Pectobacterium quasiaquaticum]
MKSLYWVGSSKKDLQSLPADVQDVFGYALHVAQTGGKHIQAKPLKGFGGAGVLEVVEDYIGDTYRAVYTVKFGESVYVLH
AFQKKSSSGIATPKPDMNTIRERLKAAENHAKGA

Nucleotide

• Length: 345 bp

>T182249 NZ_CP086369:3061792-3062103 [Pectobacterium versatile]
ATGCATGTTATTTCGCGGGCACCTTTCGACACTGCAACCACTCAGTTTCCGAATCAGGCGGCAGCACTTGATGACCTATA
TCGGGTTATCAAACGCGAAATGTATGCAACGCCGGACGATATGAAAAAACGCTTCCCTAGTCTAGATAGGATGAAATATC
GGGAAAAATGGTGGGTTATTGATATTGGTGGCGGGCATCTTCGAGTGATGTTTTTTGCTGATTTTGAGCGAGGGAAAATC
TTCATCAAGCACATCACATCCCATGCAGAGTACGACAGGCTGACAGAGTATTACCGGAGGAATAAAGAATGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11434.45 Da
• Isoelectric Point: 10.6133

>AT182249 WP_014916192.1 NZ_CP065177:c1251422-1251105 [Pectobacterium quasiaquaticum]
MSQDIEVSSGNVYADLGNVHAEDMLVKAQLATLISSIIKSRRLTQAEAAKLLGMPQPKLSNLLRGQFRGISETKMLECLT
KLGRDIQIVVGKPRRTPGSVKVVFA

Nucleotide

• Length: 318 bp

>AT182249 NZ_CP086369:3062100-3062516 [Pectobacterium versatile]
ATGATGTACGCCGACGCCATCAAGGCAGCTAACAACCTGACGAGTATCGTACCATTCCTCGGAGGCAGCACCTCTCGTAA
GGATTATGAGGATGCACTGAAACTCACTGAATACCTGATCGAGAGTGAACCTGACAGTCCGCTAATCGATATGCTGACTG
CCAAAATTGACAAATACGAAGATGATGCACCGGAGTTTGCAGCCTTCAACGAACGTGTTAAAGCACTCCCAGCAGGTATC
GCTTTACTGCGCGTCCTTATGGATCAGCATCAGCTAACGCAGAGTGATTTTGAAGCTGAGATTGGTAAAAAGTCTCTGGT
ATCCCGCATTCTAAAAGGTGAGCGCACTCTAACGCTGGATCACATGAGAGCGCTTGCTAAACGATTCAATATTCCCGTGA
GTGCTTTTGTTGATTGA