Detailed information of TA system TA182247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 500203..500786
• Replicon: chromosome
• Accession: NZ_CP065177
• Organism: Pectobacterium quasiaquaticum strain A477-S1-J17

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IG609_RS02355
• Protein ID: WP_193397854.1
• Coordinates: 500481..500786 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7V8PT23
• Locus tag: IG609_RS02350
• Protein ID: WP_010296210.1
• Coordinates: 500203..500493 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG609_RS02330 (IG609_002320)	495337..496599	-	1263	WP_193397850.1	L-rhamnose isomerase	-
IG609_RS02335 (IG609_002325)	496596..498086	-	1491	WP_193397851.1	rhamnulokinase	-
IG609_RS02340 (IG609_002330)	498423..499262	+	840	WP_193397852.1	HTH-type transcriptional activator RhaS	-
IG609_RS02345 (IG609_002335)	499287..500141	+	855	WP_193397853.1	helix-turn-helix domain-containing protein	-
IG609_RS02350 (IG609_002340)	500203..500493	+	291	WP_010296210.1	ribbon-helix-helix protein, CopG family	Antitoxin
IG609_RS02355 (IG609_002345)	500481..500786	+	306	WP_193397854.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IG609_RS02360 (IG609_002350)	500846..502555	-	1710	WP_193397855.1	ABC transporter ATP-binding protein	-
IG609_RS02365 (IG609_002355)	502552..503418	-	867	WP_010285293.1	ABC transporter permease	-
IG609_RS02370 (IG609_002360)	503411..504370	-	960	WP_193397856.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-96)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11606.46 Da
• Isoelectric Point: 9.4385

>T182247 WP_193397854.1 NZ_CP065177:500481-500786 [Pectobacterium quasiaquaticum]
MPQVIVSERAKRDLQRLQDFLKNKNALAAKKAAEVLIRGIRQLEALPNIGRPVEHLPLEYQELVIEFGSSGYVMLYRHDE
LTDRVVILTVKHQKEAGYQNP

Nucleotide

• Length: 306 bp

>T182247 NZ_CP086369:3007307-3007594 [Pectobacterium versatile]
ATGACCTATAAGTTAAAATTTGTGCCTTCTGCATTGAAGGAATGGAAAAAATTAGGGCACCCTGTCCGGGAGCAGTTCAA
GAAAAAGCTGGTTGAGCGTTTGGAAAATCCTCGTGTTCCTTCAGCCCAACTTCATGGCCGTAAAGACCAGTATAAAATTA
AACTGAAGTCCGCTGGCTACAGGCTGGTGTATTTGGTCCAGGATGAGACCATTACTGTGATGGTTATGGGCGTTGGAAAG
CGCGAAGGTAGCCAGATTTATTCTGATACTAAAGGTCGCTCTGCTTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 11064.13 Da
• Isoelectric Point: 4.7692

>AT182247 WP_010296210.1 NZ_CP065177:500203-500493 [Pectobacterium quasiaquaticum]
MADTTRQTTTLRIDQDIKERLKTLADDRNSSAHALMLEAIAEYVEREEKRSQYRKEALAAWEDYQDTGKHITADETVTWL
ESWGSGHEQDAPACHK

Nucleotide

• Length: 291 bp

>AT182247 NZ_CP086369:3007063-3007317 [Pectobacterium versatile]
ATGGCTTTCAACATCCTGACTAACACAGCCGCCAGTATTACTGAGTTGAAACGTGACCCGATGGGGACGGTACGGGCTGC
TGAAGGTGAAACTATCGCTATACTGAACCGGAATGAGCCGGCGTTCTACTGTGTGCCTCCTGCCGTATTCGCTTATTTAA
TGGAACTGGCTGAAGATGCCGAACTGGGGCGTACCGTTGATGACCGGATGTCAGAACTAGCTGACGCGGAAGAGATTTCG
CCCGATGACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A7V8PT23