182246

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 398268..398799 Replicon chromosome
Accession NZ_CP065177
Organism Pectobacterium quasiaquaticum strain A477-S1-J17

Toxin (Protein)


Gene name stbE Uniprot ID A0A086EVU3
Locus tag IG609_RS01875 Protein ID WP_039282785.1
Coordinates 398512..398799 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A1V2R9J2
Locus tag IG609_RS01870 Protein ID WP_039282788.1
Coordinates 398268..398522 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG609_RS01845 (IG609_001835) 393378..393968 - 591 WP_005975525.1 DnaA initiator-associating protein DiaA -
IG609_RS01850 (IG609_001840) 394010..394366 - 357 WP_193397224.1 YraN family protein -
IG609_RS01855 (IG609_001845) 394363..396381 - 2019 WP_193397177.1 penicillin-binding protein activator -
IG609_RS01860 (IG609_001850) 396445..397332 + 888 WP_039470360.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
IG609_RS01870 (IG609_001860) 398268..398522 + 255 WP_039282788.1 plasmid stabilization protein Antitoxin
IG609_RS01875 (IG609_001865) 398512..398799 + 288 WP_039282785.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IG609_RS01880 (IG609_001870) 398976..399761 + 786 WP_039524247.1 4,5-DOPA dioxygenase extradiol -
IG609_RS01885 (IG609_001875) 400021..401181 - 1161 WP_193397176.1 glutathionylspermidine synthase family protein -
IG609_RS01890 (IG609_001880) 401193..401867 - 675 WP_193397175.1 DUF1190 family protein -
IG609_RS01895 (IG609_001885) 402137..403531 - 1395 WP_193397174.1 outer membrane channel protein TolC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hcp 256952..430805 173853


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11011.96 Da        Isoelectric Point: 10.7694

>T182246 WP_039282785.1 NZ_CP065177:398512-398799 [Pectobacterium quasiaquaticum]
MTYKLKFVPSAMKEWKKLGHPVREQFKKKLVERLENPRVPSAQLHGRKDQYKIKLKSAGYRLVYLVQDETITVMVMGVGK
REGSQIYSDTKGRSA

Download         Length: 288 bp

>T182246 NZ_CP086369:2775160-2775435 [Pectobacterium versatile]
ATGCAGGGAAAAATAGCCAGCCTACGAAAGAAGCAGCGGGAAACACTGAGCCACATTTTCAAAACACCAGTACTTTCAGG
TGTTAAATGGTCGAGTATTGAGTCACTCGTTACTGCGTTAGGCGGTGAAATTAAGGAAGGTAGCGGGTCACGAGTGCGAT
TTTTATTGAACGGGAGTATCGCCCGGTTCCATCGTCCTCATCCGTCACCGGATACTGATAAAGGTGCCCTGGTTAGCCTG
CGTGAATGGCTGGAAAGTATAGGAGTAAAACCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9208.38 Da        Isoelectric Point: 3.7947

>AT182246 WP_039282788.1 NZ_CP065177:398268-398522 [Pectobacterium quasiaquaticum]
MAFNILTNTAASITELKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAVFAYLMELAEDAELGRTVDDRMSELADAEEIS
LDDL

Download         Length: 255 bp

>AT182246 NZ_CP086369:2775432-2775794 [Pectobacterium versatile]
ATGACGAAAGCACTCAACACACCAAATACGATGGTTGTTTCTGGACAACCTGCCATTATCAGTTACGTACCGGAAATTGG
TATGTTTCGTGGTAAGTTTATTGGCTTATCTGGCTACTGTGATTTTGTCGCCGACAGTATTAATGGCTTGAGAAGCGAGG
GTGAAATTTCGCTACGCGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAGCGTGAAGAGAAGGTGAAA
ACATTCACCCTCCGTTACCCTGAATCATTCGGGGAACGACTGACCATTGCGGCCGCTGAACGTCACATTTCAGTGAATAC
GTTTATTGTTGAAACGCTTAGCGAACACCTGAAACAGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086EVU3

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2R9J2

References