Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 169565..170182 Replicon chromosome
Accession NZ_CP065177
Organism Pectobacterium quasiaquaticum strain A477-S1-J17

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IG609_RS00755 Protein ID WP_193397751.1
Coordinates 170003..170182 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IG609_RS00750 Protein ID WP_193397752.1
Coordinates 169565..169975 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG609_RS00735 (IG609_000725) 165528..166571 - 1044 WP_193397754.1 DNA-binding transcriptional regulator CytR -
IG609_RS00740 (IG609_000730) 166798..168996 - 2199 WP_193397753.1 primosomal protein N' -
IG609_RS00745 (IG609_000735) 169267..169482 + 216 WP_010281510.1 50S ribosomal protein L31 -
IG609_RS00750 (IG609_000740) 169565..169975 - 411 WP_193397752.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IG609_RS00755 (IG609_000745) 170003..170182 - 180 WP_193397751.1 type II toxin-antitoxin system HicA family toxin Toxin
IG609_RS00760 (IG609_000750) 170266..170379 - 114 Protein_151 iron ABC transporter permease -
IG609_RS00765 (IG609_000755) 170698..171015 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
IG609_RS00770 (IG609_000760) 171203..172363 + 1161 WP_193397750.1 cystathionine gamma-synthase -
IG609_RS00775 (IG609_000765) 172366..174801 + 2436 WP_193397749.1 bifunctional aspartate kinase/homoserine dehydrogenase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6603.76 Da        Isoelectric Point: 10.7838

>T182245 WP_193397751.1 NZ_CP065177:c170182-170003 [Pectobacterium quasiaquaticum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKLGLVTIPHPKKDLPIGTVKNIRKQAGI

Download         Length: 180 bp

>T182245 NZ_CP086369:2568749-2570068 [Pectobacterium versatile]
ATGGCTGCGCTCGATGTTTACATGAACGGCTATCGGGTGGGGATTCTGACCAAAACGGGCAGTGGAGCACATCATTTTTC
CTATGATGCGAACTGGCTCGGGTTGCCGGGGAGTCGCCCCATTTCGCTTTCTATGCCGCTACGTCATCAGTCCTATCAAG
GTGATGAGGTTTATAACTTCTTCGACAATTTGTTGCCAGATAACCCGGATATCAGAAGACGGATTGTCGCCAGGCATCAC
GCGGATTCCACCCAACCGTTTGATCTGCTGGATAAAGTGGGGAAAGACAGTGTCGGGGCGTTGCAAATAGTGCCGCAGGG
TACACCTGTGCACGATATAAAAAAGATCGAATACAAAACCTTATCCGAGCAGCAGCTTGAAAACATACTGACTGGATATC
TGTCCGATGCCCCGCTGGGTATGATTGATACTGAAGACGATTTTCGTATCTCTATCGCGGGCGCACAGGAAAAGACGGCG
CTGCTTTATCTGGATGATCACTGGTGCCTGCCCTTCAGTACCACACCAACTACCCACATCATCAAGCTACCGATTGGTAA
AATCGAGAGTCACTCTTACTCAATTGATATGTCTGACAGCGTTGAAAATGAGTATCTGTGCCTGCTCATTGCCAAGGCAT
TTGGGCTGCCAGTGCCGCACTGTTTTATGATCAACGCTGGCAAGATAAAGGCGTTGGCGGTGGAGCGTTTTGATCGTAAA
TACGCCTCGGATGTCAGTTGGATTATGCGGCTACCACAAGAGGATTTTTGTCAGGTATTAAACGTTCCTTCCGCACTGAA
ATATGAAAATCATGGTGGACCGGGTATTTCCGCCATTATGTCGTTTCTATTGGGGTCGGTTGATCCAGAAAGAGATCGTT
ATCGCTTTATGCAGGCTCAGGTACTGTTTTGGCTATTGGCTGCAACGGATGGTCATGCGAAAAACTTTTCCCTGTTTATT
GAATCTGAGGGGCGATATCGACTCACACCTTTCTATGACATTCTCTCTATGTATCCGGCGATGGGCGGACGGGGAATTGA
CCGCAGAGAGGCCAAACTGGCGATGGGATTAACTGGCTCAAGAGGCAAGAAATATGCGATTGAGCAGATCTTTCCCCGAC
ATTTTTTCCAGACGGCTAAGGCCGTTGGGTTTGCCAGAGAATCGATGGAAAACATTCTGGTGGAGTTTTCAAACACCGTT
GAGACCGTTATGACGACTGTTGGAAGCCAACTGCCTGTGGATTTTCCTACTCATATCAGTGAGGCAATTCTGGCCGGATT
GCAGGCCAGATCGAGACGGCTCATGAGCGGATGGGAGTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14521.40 Da        Isoelectric Point: 4.4118

>AT182245 WP_193397752.1 NZ_CP065177:c169975-169565 [Pectobacterium quasiaquaticum]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQWAKSAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALARISSSR

Download         Length: 411 bp

>AT182245 NZ_CP086369:2568483-2568749 [Pectobacterium versatile]
ATGAAGGTCACCAACAGCAAGCAGCTTAGCAGCTACCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGGAAAGT
GGCCAGTAAAGTGGGTATTCGCCAGGATACGGTATCCAGCTTCGAGCAACATCCTGATTCCACCAAGCTGGAAACCTTCT
TTAAAATCCTGTCGGCATTGAACTTAGAACTTACTGTTACGCCCCGAAATGTGGATACCGCCAATAACGAAGCCTCTGTT
GCATCATCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References