Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4879667..4881348 Replicon chromosome
Accession NZ_CP065172
Organism Klebsiella pneumoniae strain KPN110

Toxin (Protein)


Gene name mosT Uniprot ID A0A486LFH0
Locus tag I3U25_RS23730 Protein ID WP_023328808.1
Coordinates 4879667..4880584 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag I3U25_RS23735 Protein ID WP_004177809.1
Coordinates 4880590..4881348 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3U25_RS23710 4875048..4876568 + 1521 WP_040147141.1 sugar ABC transporter ATP-binding protein -
I3U25_RS23715 4876565..4877563 + 999 WP_031592479.1 ribose ABC transporter permease -
I3U25_RS23720 4877594..4878535 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
I3U25_RS23725 4878610..4879542 + 933 WP_040147145.1 carbohydrate kinase family protein -
I3U25_RS23730 4879667..4880584 - 918 WP_023328808.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
I3U25_RS23735 4880590..4881348 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
I3U25_RS23740 4881434..4882162 - 729 WP_002885152.1 response regulator transcription factor -
I3U25_RS23745 4882435..4884582 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
I3U25_RS23750 4884812..4885498 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34660.13 Da        Isoelectric Point: 5.4707

>T182239 WP_023328808.1 NZ_CP065172:c4880584-4879667 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLVEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T182239 NZ_CP086368:c2097615-2097445 [Bordetella pertussis CS]
ATGCATTACGGCCGGCAAGGCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGATTGTCAGAT
CTACATGCTTGCGGCTTATGCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCGAACTGGTCA
AGGAGCTGTAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT182239 WP_004177809.1 NZ_CP065172:c4881348-4880590 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT182239 NZ_CP086368:c2097442-2097143 [Bordetella pertussis CS]
ATGAAAAAAGACAACACGGTGTTCAACGACCTGCAGGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACAGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGCACGCTGCAGAACTGGGAGCAAGGGCACCGCAATCCGACGGACCCTGCCATGGCG
CTTCTGAAAATAGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486LFH0

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References