Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4799279..4799795 Replicon chromosome
Accession NZ_CP065167
Organism Klebsiella pneumoniae strain KPN114

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag I3U24_RS23380 Protein ID WP_002886902.1
Coordinates 4799279..4799563 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I3U24_RS23385 Protein ID WP_002886901.1
Coordinates 4799553..4799795 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3U24_RS23355 4794696..4795004 - 309 WP_004178377.1 PTS sugar transporter subunit IIB -
I3U24_RS23360 4795089..4795262 + 174 WP_032410138.1 hypothetical protein -
I3U24_RS23365 4795265..4796008 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
I3U24_RS23370 4796365..4798503 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I3U24_RS23375 4798811..4799275 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I3U24_RS23380 4799279..4799563 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I3U24_RS23385 4799553..4799795 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I3U24_RS23390 4799873..4801783 - 1911 WP_004152270.1 BglG family transcription antiterminator -
I3U24_RS23395 4801806..4802960 - 1155 WP_002886900.1 lactonase family protein -
I3U24_RS23400 4803027..4803767 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T182219 WP_002886902.1 NZ_CP065167:c4799563-4799279 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T182219 NZ_CP086342:c2119860-2119753 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT182219 WP_002886901.1 NZ_CP065167:c4799795-4799553 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT182219 NZ_CP086342:2119907-2119973 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References